6,7-dimethoxyl-2-methylene-1-tetralone | 120536-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6,7-dimethoxyl-2-methylene-1-tetralone
• 英文别名: 6,7-dimethoxy-2-methylene-1-tetralone；6,7-Dimethoxy-2-methylidene-3,4-dihydronaphthalen-1(2H)-one；6,7-dimethoxy-2-methylidene-3,4-dihydronaphthalen-1-one
• CAS: 120536-90-5
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.252
• InChiKey: HWXDRYCXHLVREY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 6,7-二甲氧基-3,4-二氢-2H-1-萘酮 在 溶剂黄146 、 diethyl amine 作用下， 生成 6,7-dimethoxyl-2-methylene-1-tetralone
  参考文献：
  名称：

  Identification and structure–activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis

  摘要：

  We have identified a novel series of alpha-methylene carbonyl compounds through structure-activity relationship (SAR) studies with high levels of anti-proliferative activities. The lead molecule, 3-methylene-2-norbornanone (3) showed potent activity (LC50 = 3-8 muM) against mutant p53 cell types and many fold selectivity (>13-29) over wild-type p53 cells. Further, compound 3 and its analogs showed refolding of mutant p53 protein comparable to their anti-proliferative activities suggesting possible interaction with mutant p53 protein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.048

文献信息

• Novel aryloxycycloalkanolaminoalkylene aryl ketones
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0127143A2

  公开（公告）日：1984-12-05

  This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.

  本发明涉及芳氧基环烷醇氨基亚烷基芳基酮及其制备工艺和作为降压药的用途。
• EP0127143B1
  申请人：——

  公开号：EP0127143B1

  公开（公告）日：1990-03-21
• US4745222A
  申请人：——

  公开号：US4745222A

  公开（公告）日：1988-05-17
• US4868315A
  申请人：——

  公开号：US4868315A

  公开（公告）日：1989-09-19