4-(4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)butan-1-ol | 1176667-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)butan-1-ol
• 英文别名: 4-(4-methyl-5H-pyrrolo[1,2-a]quinoxalin-4-yl)butan-1-ol
• CAS: 1176667-02-9
• 化学式: C₁₆H₂₀N₂O
• 分子量: 256.348
• InChiKey: DQWYIRNMPNONTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-氨基苯基)吡咯 、 5-己炔-1-醇 在 platinum(II) bromde 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以81%的产率得到4-(4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)butan-1-ol
  参考文献：
  名称：

  Platinum-Catalyzed Formal Markownikoff’s Hydroamination/Hydroarylation Cascade of Terminal Alkynes Assisted by Tethered Hydroxyl Groups

  摘要：

  An efficient method for Markownikoff's hydroamination-hydroarylation of alkynols using PtBr2 as catalyst has been developed. The platinum-catalyzed reactions of alkynols with amino group containing aromatics were achieved in methanol over a reaction time of 6-24 h and temperature ranging from rt to 80 degrees C. This method works well for a variety of alkynols and aromatic amino compounds to give substituted pyrrolo[1,2-a]quinoxalines and indolo[3,2-c]quinolines in good to excellent yields.

  DOI：

  10.1021/jo901200j

文献信息

• Platinum-Catalyzed Formal Markownikoff’s Hydroamination/Hydroarylation Cascade of Terminal Alkynes Assisted by Tethered Hydroxyl Groups
  作者：Nitin T. Patil、Rahul D. Kavthe、Vivek S. Raut、Vaddu V. N. Reddy

  DOI：10.1021/jo901200j

  日期：2009.8.21

  An efficient method for Markownikoff's hydroamination-hydroarylation of alkynols using PtBr2 as catalyst has been developed. The platinum-catalyzed reactions of alkynols with amino group containing aromatics were achieved in methanol over a reaction time of 6-24 h and temperature ranging from rt to 80 degrees C. This method works well for a variety of alkynols and aromatic amino compounds to give substituted pyrrolo[1,2-a]quinoxalines and indolo[3,2-c]quinolines in good to excellent yields.