3-N-(furan-2-ylmethyl)-1H-1,2,4-triazole-3,5-diamine | 106580-74-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-N-(furan-2-ylmethyl)-1H-1,2,4-triazole-3,5-diamine
• CAS: 106580-74-9
• 化学式: C₇H₉N₅O
• 分子量: 179.181
• InChiKey: DEJOEPVELWHIDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-氰基-2-巯基甲基-3-(糠基)甲脒 在 一水合肼 作用下， 以 乙醇 为溶剂， 以78%的产率得到3-N-(furan-2-ylmethyl)-1H-1,2,4-triazole-3,5-diamine
  参考文献：
  名称：

  Reiter, Jozsef; Pongo, Laszlo; Somorai, Tamas, Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 401 - 408

  摘要：

  DOI：

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
  申请人：Murphy Patrick Bryan

  公开号：US20050198745A1

  公开（公告）日：2005-09-15

  Five-membered heteroaromatic keratin dyeing compounds with one, two, or three heteroatoms. This invention further relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more 5-membered heteroaromatic keratin dyeing compounds with one, tow, or three heteroatoms. This invention further relates to a method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.

  具有一个、两个或三个杂原子的五元杂芳香族角蛋白染色化合物。本发明还涉及一种用于角蛋白纤维氧化染色的组合物，该组合物包含一种适于染色的介质和一种或多种具有一个、两个或三个杂原子的五元杂芳香族角蛋白染色化合物。本发明还涉及一种对角蛋白纤维进行氧化染色的方法，包括在有氧化剂存在的情况下，在足以形成所需着色的时间内使用这种组合物。
• KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF
  申请人：The Procter and Gamble Company

  公开号：EP1737417A2

  公开（公告）日：2007-01-03
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Baron Alain D.

  公开号：US20130095140A1

  公开（公告）日：2013-04-18

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US20140341986A1
  申请人：——

  公开号：US20140341986A1

  公开（公告）日：2014-11-20