2-amino-1-methyl-1,5-dihydro-imidazol-4-one; picrate | 2244-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-amino-1-methyl-1,5-dihydro-imidazol-4-one; picrate
• 英文别名: 2-Amino-1-methyl-1,5-dihydro-imidazol-4-on; Picrat；2-Amino-1-methyl-1,5-dihydro-imidazol-4-on; gelbes Kreatininpikrat；2-Amino-1-methyl-1,5-dihydro-imidazol-4-on; Verbindung mit Picrinsaeure；2-Imino-1-methylimidazolidin-4-one;2,4,6-trinitrophenol；2-imino-1-methylimidazolidin-4-one;2,4,6-trinitrophenol
• CAS: 2244-17-9
• 化学式: C₄H₇N₃O*C₆H₃N₃O₇
• 分子量: 342.225
• InChiKey: YLCJRUYQUMQOCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  216
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  水 、 2-amino-1-methyl-1,5-dihydro-imidazol-4-one; picrate 、 亚硝酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  亚硝酸对肌酐及其某些衍生物的作用。

  摘要：

  DOI：

  10.1021/jo01162a013

文献信息

• Device for creatinine determination
  申请人：Bayer Corporation

  公开号：EP0546390A1

  公开（公告）日：1993-06-16

  Disclosed is a dry reagent system comprising an absorbent carrier incorporated with a dye precursor which undergoes a detectable response in the presence of creatinine under strongly basic conditions and which also contains a moderating agent for the strong base which is a polyglycol or a polymerized quaternary ammonium salt.

  本发明公开了一种干试剂系统，该系统由吸附载体和染料前体组成，染料前体在肌酐存在的强碱性条件下会产生可检测的反应，该系统还含有一种强碱缓和剂，该缓和剂为聚乙二醇或聚合季铵盐。
• Method for the determination of urinary protein and creatinine
  申请人：Bayer Corporation

  公开号：EP0656541A2

  公开（公告）日：1995-06-07

  Disclosed is a method for the determination of urinary protein and creatinine in a single reaction vessel using a continuous process. The method involves adjusting the pH to a level suitable for carrying out an immuno assay for the protein and making such a determination by an immuno agglutination technique. Raising the pH to a level suitable for determining the creatinine quickly dissipates the cloudiness caused by the agglutination reaction, so that the creatinine determination can be carried out without delay.

  本发明公开了一种利用连续过程在单个反应容器中测定尿蛋白和肌酐的方法。该方法包括将 pH 值调节到适合进行蛋白质免疫测定的水平，并通过免疫凝集技术进行测定。将 pH 值提高到适合测定肌酐的水平，可迅速消除凝集反应造成的浑浊，从而可立即进行肌酐测定。
• Dry reagent for creatinine assay
  申请人：Bayer Corporation

  公开号：EP0703453A1

  公开（公告）日：1996-03-27

  Disclosed is an improved method for the determination of creatinine in aqueous solution. An organic acid as creatinine reactive material, in the form of its lithium salt, is dried onto a suitable substrate. Contacting the dried reagent with the aqueous fluid containing creatinine results in solubilization of the creatinine reactive reagent thereby facilitating the colorimetric determination of the creatinine in solution.

  本发明公开了一种用于测定水溶液中肌酐的改进方法。作为肌酐活性物质的有机酸以其锂盐的形式被干燥在合适的基底上。将干燥的试剂与含有肌酐的水溶液接触，可使肌酐反应试剂溶解，从而有助于对溶液中的肌酐进行比色测定。
• Use of CO2 absorbant for stabilization of dried alkaline reagent in creatinine assay
  申请人：Bayer Corporation

  公开号：EP0766087A2

  公开（公告）日：1997-04-02

  Disclosed is an improvement to the method for the detection of creatinine in which creatinine, in aqueous solution, is contacted with a dry reagent system of an indicator for creatinine. The assay is carried out at a pH above about 11.5 which is maintained by an alkaline material. The improvement involves packaging the reagent system with a material capable of absorbing CO2 and at least some ambient water vapor. This inhibits the formation of carbonic acid thereby reducing the neutralization of the alkaline reagent system during storage to increase the shelf life and decrease the variability of the system.

  本发明是对肌酐检测方法的一种改进，在这种方法中，水溶液中的肌酐与肌酐指示剂的干试剂系统接触。检测在 pH 值高于约 11.5 的条件下进行，pH 值由碱性材料维持。改进措施包括用一种能够吸收二氧化碳和至少部分环境水蒸气的材料包装试剂系统。这就抑制了碳酸的形成，从而减少了碱性试剂系统在储存期间的中和，延长了保质期，降低了系统的可变性。
• Method for the detection of creatinine
  申请人：Bayer Corporation

  公开号：EP0814335A2

  公开（公告）日：1997-12-29

  Disclosed is a method for the determination of creatinine in urine which involves contacting a urine test sample with a reagent system containing Cu+2, a hydroperoxide and an oxidizible dye which provides a detectable response when oxidized in the presence of a pseudoperoxide. The reagent system also includes a buffer to maintain the urine's pH within the range of 6.6 to 8.0 and a chelating agent for the cupric ions to prevent oxidation of the dye in the absence of creatinine.

  本发明公开了一种测定尿液中肌酐的方法，该方法是将尿液检测样本与含有 Cu+2、过氧化氢和可氧化染料的试剂系统接触，当染料在假过氧化物存在下被氧化时，会产生可检测的反应。试剂系统还包括一种缓冲剂，用于将尿液的 pH 值保持在 6.6 至 8.0 的范围内，以及一种铜离子螯合剂，用于防止染料在肌酐不存在的情况下被氧化。