N-tritylhydroxylamine | 66448-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-tritylhydroxylamine
• 英文别名: Triphenylmethylhydroxylamine
• CAS: 66448-00-8
• 化学式: C₁₉H₁₇NO
• 分子量: 275.35
• InChiKey: ALCSCNYDTSWHDD-UHFFFAOYSA-N

物化性质

• 熔点：
  130-137 °C
• 沸点：
  458.3±55.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-tritylhydroxylamine 在 N-甲基吗啉 、 potassium carbonate 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.08h， 生成 ((1aR,7aS,10aS,10bS,E)-1a-methyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[2′,3′:9,10]cyclodeca[1,2-b]furan-5-yl)methyl (E)-3-(4-((7-oxo-7-((trityloxy)amino)heptyl)oxy)phenyl)acrylate
  参考文献：
  名称：

  倍半萜内酯—SAHA衍生物的制备方法及其在制备抗癌药物中的用途

  摘要：

  本发明提供了式(I)的倍半萜内酯—SAHA衍生物的制备方法以及在治疗癌症的药物中的用途，其中癌症为白血病。

  公开号：

  CN111454274B
• 作为产物：
  描述：

  三苯基氯甲烷 生成 N-tritylhydroxylamine
  参考文献：
  名称：

  Mothwurf, Chemische Berichte, 1904, vol. 37, p. 3157

  摘要：

  DOI：

文献信息

• N-Tritylhydroxylamines: preparations, structures, base strengths, and reactions with nitrous acid and perchloric acid
  作者：Moisés Canle L.、William Clegg、Ibrahim Demirtas、Mark R. J. Elsegood、Johanna Haider、Howard Maskill、Peter C. Miatt

  DOI：10.1039/b103569j

  日期：——

  N-Trityl, N-(4-methoxytrityl), N-(4,4′-dimethoxytrityl), and N-(4,4′,4″-trimethoxytrityl) derivatives of hydroxylamine, O-methylhydroxylamine, and O-benzylhydroxylamine have been prepared and characterised. Additionally, N,O-ditrityl- and N,O-bis(4,4′-dimethoxytrityl)-hydroxylamines have been made, and the X-ray crystal structure of the former has been determined. The pKa value of O-benzylhydroxylammonium in water (6.2) and of its N-trityl analogue in aqueous acetonitrile (7.5) have been measured. The N-tritylhydroxylamines all decompose under aqueous acidic conditions to give the corresponding trityl alcohols, and rate constants for uncatalysed and hydronium ion catalysed reactions of N-(4,4′-dimethoxytrityl)-O-methylhydroxylamine have been measured by stopped flow kinetics at 25 °C. This compound compares in reactivity with N-alkyl-N-(4,4′-dimethoxytrityl)amines rather than with 4,4′-dimethoxytritylamine. Attempted nitrosation of N-tritylhydroxylamine and its O-alkyl derivatives gave trityl alcohol, the intermediate N-nitroso compound being detectable but too unstable to isolate. From N-trityl-O-benzylhydroxylamine, attempted nitrosation led to the formation of triphenylmethane in addition to trityl alcohol, benzyl alcohol, and trityl benzyl ether. The mildly acidic conditions used for attempted nitrosation of methoxy-substituted N-tritylhydroxylamines led to deamination before addition of the nitrosating agent.

  已经制备并表征了羟胺、O-甲基羟胺和O-苄基羟胺的N-三苯甲基、N-(4-甲氧基三苯甲基)、N-(4,4'-二甲氧基三苯甲基)和N-(4,4',4''-三甲氧基三苯甲基)衍生物。此外，还制备了N,O-二三苯甲基和N,O-双(4,4'-二甲氧基三苯甲基)羟胺，并测定了前者的X射线晶体结构。测量了O-苄基羟胺盐在水中(pKa 6.2)及其N-三苯甲基类似物在乙腈水溶液中(pKa 7.5)的pKa值。所有N-三苯甲基羟胺在酸性水溶液条件下均分解生成相应的三苯甲基醇，通过停流动力学在25°C下测量了N-(4,4'-二甲氧基三苯甲基)-O-甲基羟胺的无催化反应和质子催化反应的速率常数。该化合物的反应性介于N-烷基-N-(4,4'-二甲氧基三苯甲基)胺和4,4'-二甲氧基三苯甲基胺之间。试图对N-三苯甲基羟胺及其O-烷基衍生物进行亚硝化反应，生成三苯甲基醇，中间体N-亚硝基化合物可检测到但过于不稳定而无法分离。从N-三苯甲基-O-苄基羟胺出发，试图进行亚硝化反应除了生成三苯甲基醇外，还形成了三苯甲烷、苄醇和三苯甲基苄基醚。对甲氧基取代的N-三苯甲基羟胺试图进行亚硝化反应时的轻微酸性条件，在加入亚硝化试剂之前先发生了脱氨反应。
• [EN] PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS<br/>[FR] DERIVES DE PYRAZOLO-QUINAZOLINE, PROCEDE DE PREPARATION ASSOCIE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASE
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2004104007A1

  公开（公告）日：2004-12-02

  Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了配方(Ia)或(Ib)中定义的吡唑喹唑啉衍生物及其药用盐，其制备方法以及包含它们的药物组合物；本发明的化合物可能在治疗中对与异常蛋白激酶活性相关的疾病，如癌症，具有用处。
• [EN] SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE MMP-12 ET MMP-13 À BASE D'ACIDE HYDROXAMIQUE
  申请人：NOVARTIS AG

  公开号：WO2010007027A1

  公开（公告）日：2010-01-21

  The present invention provides a compound of formula (I) said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP- 13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-12 and/or MMP-13. Finally, the present invention also provides pharmaceutical composition that include the compound of formula (I).

  本发明提供了一种具有化学式(I)的化合物，该化合物是MMP-12和/或MMP-13的抑制剂，因此可用于治疗由MMP-12和/或MMP-13异常活性特征的疾病或疾病。因此，化合物的化学式(I)可用于治疗由MMP-12和/或MMP-13介导的疾病或疾病。最后，本发明还提供了包括化学式(I)的化合物的药物组合物。
• [EN] NOVEL INHIBITORS OF MEPRIN ALPHA AND BETA<br/>[FR] NOUVEAUX INHIBITEURS DE LA MÉPRINE ALPHA ET BÊTA
  申请人：FRAUNHOFER GES FORSCHUNG

  公开号：WO2017182433A1

  公开（公告）日：2017-10-26

  The present invention relates to novel hydroxamic acid derivatives as inhibitors of meprin β and/or α, pharmaceutical compositions comprising such compounds, methods for treatment or prophylaxis of diseases or conditions, especially such that are related to meprin β and/or α, and compounds and pharmaceutical compositions for use in such methods.

  本发明涉及新型羟羧酸衍生物，作为酶酶β和/或α的抑制剂，包括这些化合物的药物组合物，用于治疗或预防疾病或症状的方法，特别是与酶酶β和/或α相关的疾病或症状，并且用于这些方法的化合物和药物组合物。
• Imidazole-based compounds, compositions comprising them and methods of their use
  申请人：Augeri J. David

  公开号：US20070208063A1

  公开（公告）日：2007-09-06

  Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:

  基于咪唑的化合物、包含它们的组合物以及它们用于治疗、预防和管理炎症性和自身免疫性疾病和紊乱的方法被披露。特定的化合物具有如下式I：