[4-[(Z)-2-(4-phenylphenyl)ethenyl]phenyl]methanol | 353739-81-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [4-[(Z)-2-(4-phenylphenyl)ethenyl]phenyl]methanol
• CAS: 353739-81-8
• 化学式: C₂₁H₁₈O
• 分子量: 286.373
• InChiKey: JKFDIAIUBPNRIT-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [4-[(Z)-2-(4-phenylphenyl)ethenyl]phenyl]methanol 在 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 [4-[(E)-2-(4-phenylphenyl)ethenyl]phenyl]methyl 5-methyl-3-(4-nitrophenyl)-4H-1,2-oxazole-5-carboxylate
  参考文献：
  名称：

  Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

  摘要：

  DOI：

  10.1002/1521-3773(20010518)40:10<1875::aid-anie1875>3.0.co;2-5
• 作为产物：
  描述：

  1-(2,2-二溴乙烯基)-4-苯基苯 在 四(三苯基膦)钯 四丁基氟化铵 、 叔丁基锂 、 三正丁基氢锡 作用下， 以 二氯甲烷 为溶剂， 生成 [4-[(Z)-2-(4-phenylphenyl)ethenyl]phenyl]methanol
  参考文献：
  名称：

  Precipiton strategies applied to the isolation of α-substituted β-ketoesters

  摘要：

  Diaryl alkene 1Z is a 'precipiton', a protecting group that allows reaction products to be isolated by simple filtration. Here we illustrate the use of this protecting group for the preparation and isolation, without distillation or chromatography, of pure cc-substituted beta -ketoesters. The precipiton 1Z was prepared in 43% overall yield. It is anticipated that development of precipiton-based syntheses will provide a new alternative for automated reaction product isolation that may be useful for bench-scale and process-scale chemical preparations. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00726-2

文献信息

• Precipiton strategies applied to the isolation of α-substituted β-ketoesters
  作者：Todd Bosanac、Craig S Wilcox

  DOI：10.1016/s0040-4039(01)00726-2

  日期：2001.6

  Diaryl alkene 1Z is a 'precipiton', a protecting group that allows reaction products to be isolated by simple filtration. Here we illustrate the use of this protecting group for the preparation and isolation, without distillation or chromatography, of pure cc-substituted beta -ketoesters. The precipiton 1Z was prepared in 43% overall yield. It is anticipated that development of precipiton-based syntheses will provide a new alternative for automated reaction product isolation that may be useful for bench-scale and process-scale chemical preparations. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis
  作者：Todd Bosanac、Jaemoon Yang、Craig S. Wilcox

  DOI：10.1002/1521-3773(20010518)40:10<1875::aid-anie1875>3.0.co;2-5

  日期：2001.5.18