allyl choline phosphate | 77075-58-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: allyl choline phosphate
• 英文别名: allylphosphorylcholine；allyl phosphorylcholine；APC；Prop-2-enyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 77075-58-2
• 化学式: C₈H₁₈NO₄P
• 分子量: 223.209
• InChiKey: DAJOGJKFUNIVKY-UHFFFAOYSA-N

物化性质

• 熔点：
  166-168 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  巯丙基三甲氧基硅烷 、 allyl choline phosphate 在 二苯甲酮 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以100%的产率得到
  参考文献：
  名称：

  用作表面改性剂的烷氧基硅烷化磷酸胆碱的简便合成：CuAAC和硫醇-烯“喀哒”反应†

  摘要：

  从CuAAC（铜催化的叠氮化物/炔烃环加成反应）和硫醇-烯“点击”反应中合成了八种烷氧基硅烷化的磷酰胆碱（PC）化合物。该方法学将为合成烷氧基硅烷化的PC改性剂提供简单有效的途径。为了证明这些产品的改性能力，将它们植入二氧化硅珠上，并定量了负载率。

  DOI：

  10.1039/c4ra15716h
• 作为产物：
  描述：

  methyl allyl 2-(dimethylamino)ethyl phosphate 反应 672.0h， 生成 allyl choline phosphate
  参考文献：
  名称：

  胆碱烷基磷酸酯的简单合成

  摘要：

  制备了烷基（2-二甲基氨基）乙基甲基磷酸酯，并将其平滑异构化为相应的烷基胆碱磷酸酯。

  DOI：

  10.1016/s0040-4039(00)71474-2

文献信息

• Method for the synthesis of phospholipid ethers
  申请人：Pinchuk Anatoly

  公开号：US20080312459A1

  公开（公告）日：2008-12-18

  Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.

  揭示了改进的合成磷脂醚类似物和烷基磷胆碱类似物的方法。这些方法允许使用更多种反应物，并更容易合成不同长度的烷基链，同时在室温或更低温度下进行反应。本文所披露的方法提供了使用烷基卤化物和有机锌试剂的反应物和条件，不使用格林纳德反应，从而使它们更容易分离并提高产品的纯度。通过本文披露的方法合成的PLE化合物也可用于合成高特异活性的磷脂醚（PLE）类似物，用于癌症的治疗和诊断。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• 황-가교화된 알콕시실란화 포스포릴콜린의 제조방법
  申请人：UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS 연세대학교 원주산학협력단(120120107738) Corp. No ▼ 141271-0004893BRN ▼224-82-14988

  公开号：KR20170010417A

  公开（公告）日：2017-01-31

  본 발명은 알케닐포스포릴콜린(alkenyl phosphorylcholine)을 티올-엔(thiol-ene) 클릭(click) 반응에 따라 하기 화학식 1로 표시되는 티올 화합물과 반응시켜 황-가교화된(sulfur-bridged) 알콕시실란화포스포릴콜린(alkoxysilanated phosphorylcholine)을 제조하는 방법에 관한 것으로서 [화학식 1] 상기 화학식 1에서, R, R 및 R는 각각 수소, (C-C) 알콕시, 비치환된 (C-C) 직쇄 또는 분지쇄알킬, 치환된 (C-C) 직쇄 또는 분지쇄알킬, 할로겐, 하이드록실, 페닐 및 벤질로 이루어진 그룹으로부터 선택되고, R, R 및 R 중 적어도 하나는 (C-C) 알콕시이고, m은 1 내지 7로부터 선택되는 정수이며, 본 발명에서는 구리(I)-촉매 및 티올-렌(thiol-ene) “클릭” 반응이 알콕시실란화 PC 모이어티를 합성하는 매우 간편하고 효율적인 방법을 제공한다는 점을 규명하였고, 총 12종의 알콕시실란화 PC를 매우 고수율로 수득할 수 있었으며, 본 발명에 따른 방법으로 수득된 알콕시실란화 PC가 표면 개질제로 사용될 수 있다는 점을 실험을 통해 규명하였으며, 또한 본 발명에서, 알콕시실란화 PC는 실리카비드 표면에 임플란트되었고, 로딩율을 정량함으로써 알콕시실란화 PC가 실리카비드 표면에 성공적으로 임플란트 되었다는 점을 규명하였다.

  本发明涉及一种通过将烯基磷酰胆碱(alkenyl phosphorylcholine)与硫醚烯(thiol-ene)点击(click)反应中显示为化学式1的硫醚化合物反应，制备硫桥联的硅烷化磷脂胆碱(alkoxysilanated phosphorylcholine)的方法。在上述化学式1中，R、R和R分别选自氢、(C-C)烷氧基、非取代的(C-C)直链或支链烷基、取代的(C-C)直链或支链烷基、卤素、羟基、苯基和苄基组成的基团，其中至少一个为(C-C)烷氧基，m为选定的1至7之间的整数。本发明证明了铜(I)催化剂和硫醚烯(thiol-ene)“点击”反应是一种非常简便高效的合成硅烷化 PC 接头的方法，并且成功地获得了12种硅烷化 PC 产物，并通过实验证明了根据本发明的方法获得的硅烷化 PC 可用作表面改性剂，此外，在本发明中，硅烷化 PC 已植入硅胶表面，并通过定量载荷证明了硅烷化 PC 已成功植入硅胶表面。
• Mucosal formulation
  申请人：Boga Rameshbabu

  公开号：US20070264206A1

  公开（公告）日：2007-11-15

  A mucosal formulation for administration to mucosal membranes, such as in the mouth, nasal passage, stomach, vagina, etc., is disclosed. The mucosal formulation contains a lipid-pharmaceutical agent complex formed from phospholipids possessing a hydrophobic moiety that orients into a hydrophobic phase and a polar head moiety that orients towards the aqueous phase (i.e., “amphipathic” lipids). When placed in an aqueous medium (e.g., vaginal fluid), the phospholipids form liposomes or other small lipid vesicles (e.g., micelles) that may then be used to deliver pharmaceutical agents into a living organism.

  揭示了一种用于给粘膜膜的制剂，例如口腔、鼻腔、胃、阴道等。这种粘膜制剂包含从磷脂中形成的含有疏水部分的脂质-药物复合物，该疏水部分朝向疏水相，极性头部分朝向水相（即“两性”脂质）。当置于水性介质中（例如阴道液），磷脂形成脂质体或其他小的脂质囊泡（例如胶束），然后可用于将药物输送到活体内。
• Phospholipid Ether Analogs as Cancer-Targeting Drug Vehicles
  申请人：Cellectar Biosciences, Inc.

  公开号：US20160136190A1

  公开（公告）日：2016-05-19

  The present invention is directed to therapeutic compounds capable of targeting cancer cells and cancer stem cells. The present invention is further directed to compositions comprising these therapeutic compounds and methods of treating cancer comprising administering these therapeutic compounds.

  本发明旨在针对癌细胞和癌干细胞的治疗化合物。本发明进一步涉及包含这些治疗化合物的组合物和治疗癌症的方法，其中包括给予这些治疗化合物。