Choline methyl ether chloride | 6340-44-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Choline methyl ether chloride
• 英文别名: (2-methoxyethyl)trimethylammonium chloride；methoxycholine chloride；(2-methoxy-ethyl)-trimethyl-ammonium; chloride；(2-Methoxy-aethyl)-trimethyl-ammonium; Chlorid；2-(methoxy)ethyltrimethylammonium chloride；2-methoxyethyl(trimethyl)azanium;chloride
• CAS: 6340-44-9
• 化学式: C₆H₁₆NO*Cl
• 分子量: 153.652
• InChiKey: MSIGGUSMCUUDGY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.66
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,8,13-trimethoxy-7,12-diphosphono-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ylphosphonic acid 、 Choline methyl ether chloride 生成 C₆H₁₆NO⁽¹⁺⁾*C₂₄H₂₇O₁₂P₃*Cl^(1-)
  参考文献：
  名称：

  C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition

  摘要：

  提出了一种获取荧光环三藜芦烯（CTV）探针的新策略。关键中间体三碘CTV通过3步合成，整体产率为47%。整个合成过程仅需一次纯化步骤。通过合成能够在拟生理条件下选择性结合胆碱和乙酰胆碱的荧光磷酸化探针，展示了这种三碘CTV作为中间体的潜力。因此，这一中间体应该能使我们快速形成探针库，以凸显最有前景的探针。

  DOI：

  10.1039/c1ob06231j
• 作为产物：
  描述：

  2-氯乙基甲基醚 、 三甲胺 以 水 、 乙腈 为溶剂， 反应 5.5h， 以100%的产率得到Choline methyl ether chloride
  参考文献：
  名称：

  新型疏水离子液体在硝酸介质中萃取铀（vi）的应用及确定形成的铀酰配合物

  摘要：

  合成和表征了新型的基于铵的疏水离子液体（ILs），并将其用于硝酸水溶液中液-液萃取铀（VI）的过程中。三ñ丁基磷酸盐（TBP），进行了研究。在改变硝酸浓度时，发现每个IL给出明显不同的结果。相对亲水的离子液体在0.01 M硝酸溶液中显示出较高的铀（VI）萃取能力，从0.01到2 M逐渐降低HNO 3然后随着硝酸浓度增加至6 M而再次增加。对一种此类IL涉及的机理的分析指出，阳离子交换是低硝酸浓度时的主要途径，而在高硝酸浓度时，阴离子交换是主要途径。占主导地位。疏水性强的离子液体对硝酸浓度低于0.1 M的萃取性较低，但可萃取性从0.1 M增加至6 M硝酸。在这种情况下，主要机制涉及中性铀酰复合物的分配。铀酰络合物被认为是UO 2 2+ ·（TBP）3对于阳离子交换机制，UO 2（NO 3）2（TBP）2为中性机构和UO 2（NO 3）3 - ·（TBP）用于阴离子交换机理。

  DOI：

  10.1039/c1dt10755k

文献信息

• Thiomolybdate analogues and uses thereof
  申请人：——

  公开号：US20040019043A1

  公开（公告）日：2004-01-29

  The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization.

  当前的发明提供了新颖的硫代钼酸盐衍生物，制备新颖的硫代钼酸盐衍生物的方法，新颖的硫代钼酸盐衍生物的药物组合物，使用新颖的硫代钼酸盐衍生物治疗与异常血管生成相关的疾病的方法，以及使用硫代钼酸盐衍生物药物组合物治疗与异常血管生成相关的疾病的方法。
• Method and composition for coiontophoresis
  申请人：Becton Dickinson and Company

  公开号：EP0448300A2

  公开（公告）日：1991-09-25

  Methods for changing the delivery of an active ingredient to the vasculature of an animal by iontophoresis have the steps of adding a vasoactivator to a formulation with an active ingredient, coiontophoresing the vasoactivator and the active ingredient into the skin of an animal and establishing a concentration of the vasoactivator in the skin near the upper capillary loops thereof so that the blood flow is changed therethrough. The vasoactivator effectively changes the blood flow in the upper capillary loops of the vasculature in the skin of an animal. If the vasoactivator is a vasodilator, the blood flow is increased and when the vasoactivator is a vasoconstrictor, the blood flow is decreased. An iontophoretic delivery apparatus for use with a formulation for controlling iontophoretic transdermal administration of an active ingredient into the blood stream of the vasculature of an animal has a donor reservoir and an indifferent reservoir with an electric field therebetween for the flow of ions thereacross. The formulation is associated with the donor reservoir for coiontophoresis along the electric field to the indifferent reservoir. The vasoactivator in the formulation changes the blood flow in the upper capillary loops controlling the introduction of the active ingredient into the blood stream of the animal. A composition for coiontophoretic delivery has a solution of an active ingredient and a vasoactivator in a polar liquid.

  通过离子透入法改变向动物血管输送活性成分的方法包括以下步骤：在含有活性成分的制剂中加入血管活化剂，将血管活化剂和活性成分共离子透入动物皮肤，并在其上部毛细血管环附近的皮肤中建立血管活化剂浓度，从而改变通过该处的血流。血管活化剂可有效改变动物皮肤血管上部毛细血管环的血流量。如果血管活化剂是一种血管扩张剂，血流量就会增加；如果血管活化剂是一种血管收缩剂，血流量就会减少。一种用于控制活性成分离子透皮给药进入动物血管血流的制剂的离子透皮给药装置有一个供体贮液器和一个无关贮液器，两者之间有一个电场，用于离子在两者之间流动。制剂与供体贮槽相连，沿电场向非供体贮槽渗透。制剂中的血管活化剂可改变上部毛细管环路中的血流，控制活性成分进入动物血流。共渗给药组合物是活性成分和血管活化剂在极性液体中的溶液。
• Pharmaceutical product comprising a parci-symphatic-mimetic drug having therapeutic properties on the human sensibility and autocinesis in general
  申请人：Santini, Maurizio

  公开号：EP0533639A1

  公开（公告）日：1993-03-24

  There is disclosed a pharmaceutic product which is adapted to radically interfere against the algic pathology phenomena. This product comprises parasympathicmimetic drugs, in particular carbachol or methacholine and it has a broad application in the medical and neurology clinic field.

  本研究公开了一种能够从根本上干预藻类病理现象的医药产品。该产品包括拟副交感神经药物，特别是卡巴胆碱或甲氧胆碱，在医疗和神经学临床领域有着广泛的应用。
• Fluoropolymer blend and articles thereof
  申请人：Fukushi Tatsuo

  公开号：US10358584B2

  公开（公告）日：2019-07-23

  Described herein is a composition, article and method thereof, wherein the composition comprises (i) a fluoropolymer and (ii) an ionic liquid.

  本文描述了一种组合物、物品及其方法，其中组合物包括 (i) 含氟聚合物和 (ii) 离子液体。
• The Importance of Molecular Parameters of Quaternary Ammonium Salts in Their Antigibberellin (Retardant) Activity
  作者：R. G. Gafurov、V. Yu. Grigor'ev、A. N. Proshin、V. G. Chistyakov、I. V. Martynov、N. S. Zefirov

  DOI：10.1023/b:rubi.0000049778.67576.cc

  日期：2004.11

  The importance of six theoretically calculated molecular parameters in the antigibberellin (retardant) activity of quaternary ammonium salts is studied using a regression analysis. A bioassay system based on cell culture of fungus Gibberella fujikuroi is used to determine the activity. In the case of N,N,N-trimethyl-N(2-hydroxyethyl)ammonium chloride (choline) and N,N,N-triethyl-N-(2-hydroxyethyl)ammonium chloride (N,N,N-triethylcholine) derivatives with linear structure, the polarizability, proton acceptor activity, and lipophilicity of these compounds exert the largest effect on the antigibberellin activity. The antigibberellin activity of more sterically hindered N,N-dialkylpiperidinium salts was mainly defined by the steric parameter, while the polarizability, proton acceptor activity, and (through them) lipophilicity exert a lesser effect. Other parameters are of minor importance for the three groups of compounds studied.