Bi(2-C4H3Se)3 | 861149-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硒吩
• 英文名称: Bi(2-C4H3Se)3
• 英文别名: tris(selenophen-2-yl)bismuthine；Tri(selenophen-2-yl)bismuthane；tri(selenophen-2-yl)bismuthane
• CAS: 861149-96-4
• 化学式: C₁₂H₉BiSe₃
• 分子量: 599.064
• InChiKey: PWQOKVFXUQUSIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.25
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  氯化铋 、 (2-selenophene-2-yl)lithium 以 四氢呋喃 、 乙醚 为溶剂， 以62%的产率得到Bi(2-C4H3Se)3
  参考文献：
  名称：

  First synthesis and structural report on selenophen-2-yl containing pnictogens: Biological activities of tris(selenophen-2-yl)stibine

  摘要：

  A new tertiary stibine and bismuthine containing C-heterocyclic selenophene ring have been synthesized. Tris(2-selenophenyl)stibine (1) and tris(2-selenophenyl) bismuthine (2) and characterized by IR, MS, H-1, C-13, COSY, HETCOR NMR spectroscopy. Crystal structures of stibine and bismuthine have been determined. In an attempted synthesis of tris(2-selenophenyl) phosphine, an oxidative product tris(2-selenophenyl) phosphine oxide (3) was isolated under the experimental conditions used, whose X-ray crystal structure was also determined. To best of our knowledge C-heterocyclic selenophene-2-yl pnictogens are first of their kind, as not many examples are known even with other p-block metal/metalloids.The biological activity of compound (1) was determined. The compound (1) shows a significant selectivity (> 85%) for carcinogenic cell K and U growth inhibition. The toxicity of tris(selenophen-2-yl) stibine (1) on larvae of Artemia Salina was studied and the LC50 value was 589.6 mu M. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.03.047

文献信息

• Heteroaryl bismuthines: a novel synthetic concept and metal⋯π heteroarene interactions
  作者：A. M. Preda、W. B. Schneider、M. Rainer、T. Rüffer、D. Schaarschmidt、H. Lang、M. Mehring

  DOI：10.1039/c7dt01437f

  日期：——

  provides the bismuth oxido cluster [Bi4O2OCMe2(2-C4H3S)}8] (2). In contrast, the reaction of Bi(OtBu)3 and Bi[N(SiMe3)2]3 with the silanols HOSiMe2(2-C4H3X) (X = O, S, Se, and NMe), HOSiMe2(2-C4H2S-5-SiMe3) and HOSiMe2(3-C4H3S) leads to the formation of tris(heteroaryl)bismuthines Bi(2-C4H2X-5-R)3 [where X = O, R = H (3); X = S, R = H (4); X = S, R = SiMe3 (5); X = NMe, R = H (6); X = Se, R = H (7)] and

  通过三个当量的反应形成醇盐Bi [OCMe 2（2-C 4 H 3 S）] 3（1）。用Bi（O t Bu）3制备醇HOCMe 2（2-C 4 H 3 S），然后水解得到铋氧化簇[Bi 4 O 2 OCMe 2（2-C 4 H 3 S）} 8 ] （2）。相反，Bi（O t Bu）3和Bi [N（SiMe 3）2 ] 3的反应与硅烷醇HOSiMe 2（2-C 4 H 3 X）（X = O，S，Se和NMe），HOSiMe 2（2-C 4 H 2 S-5-SiMe 3）和HOS​​iMe 2（3-C 4 H 3 S）导致形成三（杂芳基）双突变蛋白Bi（2-C 4 H 2 X-5-R）3 [其中X = O，R = H（3）; X = S，R = H（4）；X = S，R = SiMe 3（5）；X = NMe，R = H（6）; X = Se，R = H（7）]和Bi（3-C 4 H 3 S）3（