trimethyl-(3-chloro-2-hydroxy-propyl)-ammonium hydroxide | 82914-58-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trimethyl-(3-chloro-2-hydroxy-propyl)-ammonium hydroxide
• 英文别名: Trimethyl-(3-chlor-2-hydroxy-propyl)-ammoniumhydroxyd；Trimethyl-(γ-chlor-β-oxy-propyl)-ammoniumhydroxyd；3-Chlor-2-hydroxy-1-trimethylammonio-propan；3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium；(3-chloro-2-hydroxypropyl)-trimethylazanium
• CAS: 82914-58-7
• 化学式: C₆H₁₅ClNO
• 分子量: 152.644
• InChiKey: XIUCEANTZSXBQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,3-二氯丙醇 、 三甲胺 生成 trimethyl-(3-chloro-2-hydroxy-propyl)-ammonium hydroxide 、 prolonium chloride
  参考文献：
  名称：

  Niemilowicz, Monatshefte fur Chemie, 1886, vol. 7, p. 249

  摘要：

  DOI：

文献信息

• Formulations designed to be applied on keratinous material and to be rinsed
  申请人：Anthony Olivier

  公开号：US20060107469A1

  公开（公告）日：2006-05-25

  The invention concerns a formulation designed to be applied on keratinous material such as the skin, the hair, and to be rinsed with an aqueous rinsing medium, in the form of a stable dispersion for a pH ranging between 3 and 5.5, and comprising at least one active substance, a vector agent consisting of at least one organic polymer capable of bringing said active substance to the surface of the keratinous material during the rinsing process, and optionally at least one salt soluble in the formulation; the active substance, whether or not in liquid form, has in the medium of the formulation, a global cationic or zero charge; it is insoluble in the formulation medium and stabilized by means of a cationic surfactant and it remains insoluble or tends to swell in the rinsing medium; the invention also concerns methods for treating keratinous material using said formulation, as well as the use of a vector agent consisting of at least an organic polymer in the formulation as agent capable of bringing the active matter to the surface of the keratinous matter during the rinsing process

  该发明涉及一种配方，旨在涂抹在角质素材料上，如皮肤、头发，并用含水冲洗介质冲洗，形式为稳定分散液，pH值在3至5.5之间，包括至少一种活性物质，一种载体剂，由至少一种有机聚合物组成，能够在冲洗过程中将该活性物质带到角质素材料表面，并且在配方中可溶的至少一种盐；该活性物质，无论是液体形式与否，在配方介质中具有全局阳离子或零电荷；它在配方介质中不溶解，并通过阳离子表面活性剂稳定，并保持不溶解或在冲洗介质中膨胀；该发明还涉及使用该配方处理角质素材料的方法，以及使用至少一种有机聚合物作为载体剂在配方中，作为在冲洗过程中将活性物质带到角质素材料表面的能力。
• PREPARATION METHOD OF HIGH-PURITY L-CARNITINE
  申请人：Gu Shuhua

  公开号：US20110263897A1

  公开（公告）日：2011-10-27

  The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of quality control in different steps of chiral medicine production. The method comprises the following steps of: monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral column and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derviation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomerless than 2%.

  本发明涉及高纯度L-肉碱的制备方法，属于手性药物生产不同步骤的质量控制的重要技术。该方法包括以下步骤：通过气相色谱和手性柱监测手性原料S-环氧氯丙烷中L-异构体杂质的含量，并控制手性原料中L-异构体杂质的含量在一定范围内；使用旋光仪监测和控制手性中间体L-3-氯-2-羟基-N，N，N-三甲基丙胺在一定范围内的比旋光度；通过HPLC使用衍生剂（+）α-甲基-6-甲氧基-2-萘乙酰氯监测中间体L-3-氰-2-羟基-N，N，N-三甲基丙胺中R-异构体的含量，并控制中间体中异构体的含量在一定范围内；通过HPLC使用衍生剂（+）α-甲基-6-甲氧基-2-萘乙酰氯测量最终产品L-肉碱。该方法可得到高纯度的L-肉碱，其中L-异构体的含量可达97%以上，R-异构体的含量小于2%。
• Cation-modified galactomannan polysaccharide and cosmetic composition containing the same
  申请人：Takeda Hiromitsu

  公开号：US20060275235A1

  公开（公告）日：2006-12-07

  The present invention provides a cation-modified galactomannan polysaccharide which gives excellent conditioning effects and gives good feeling and flexibility when it is used in a hair treatment composition, and improves feeling of use by conditioning effects and emulsification conditions when it is used in a skin cosmetic composition such as body cleansing agent. Concretely, the present invention provides a cation-modified galactomannan polysaccharide obtained by substituting some of hydroxyl groups contained in an cation-modified galactomannan polysaccharide which is nonionic polysaccharide and constitutes mannose as a main chain and galactose as a side chain and the composition ratio of mannose and galactose is 1:1 and obtained from albumen portion of a seed of fenugreek ( Trigonella foenum - graecum ) which is a leguminus plant, with a specific quaternary nitrogen-containing group, and a cosmetic composition containing the cation-modified cation-modified galactomannan.

  本发明提供了一种阳离子修饰的半乳糖聚糖多糖，当用于头发护理组合物时，能够提供优异的调理效果，并在使用时给人良好的感觉和柔软度；当用于皮肤化妆品组合物，例如身体清洁剂时，能够通过调理效果和乳化条件来提高使用感受。具体而言，本发明提供了一种阳离子修饰的半乳糖聚糖多糖，其通过用具有特定季铵氮含量的阳离子修饰代替非离子聚糖中含有的一些羟基，该聚糖以甘露糖为主链，以半乳糖为侧链，甘露糖和半乳糖的组成比为1:1，该聚糖来源于胡芦巴（Trigonella foenum-graecum）的种子蛋白质部分。同时，本发明还提供了一种含有该阳离子修饰的半乳糖聚糖多糖的化妆品组合物。
• QUATERNARY AMMONIUM COMPOUND, AND AGENT FOR SUPPRESSION OF GENERATION OF VOLATILE ORGANIC COMPOUND FROM POLYACETAL BY USE OF THE SAME
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：US20190161433A1

  公开（公告）日：2019-05-30

  A quaternary ammonium compound represented by the following formula (1): [(R1) m (R2) 4-m N + ] n X n− (1) wherein each R1 independently represents an unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms; an aryl group having 6 to 20 carbon atoms; an aralkyl group where an unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms is substituted with at least one aryl group having 6 to 20 carbon atoms; or an alkylaryl group where an aryl group having 6 to 20 carbon atoms is substituted with at least one unsubstituted alkyl group or substituted alkyl group having 1 to 30 carbon atoms; each R2 independently represents a group having 2 to 60 carbon atoms and 2 to 30 oxygen atoms, the group represented by the following formula: —(RO)k-H, wherein R represents a substituted or unsubstituted alkyl group and k represents a natural number of 2 or more.

  以下是用中文翻译的结果： 一种四元铵化合物，由以下公式（1）表示：[(R1)m(R2)4-mN+]nXn−（1）其中，每个R1独立地表示未取代的1至30个碳原子的烷基或取代的烷基；具有6至20个碳原子的芳基；取代的1至30个碳原子的烷基或取代的烷基被至少一个具有6至20个碳原子的芳基取代的芳基烷基；或者，具有6至20个碳原子的芳基被至少一个未取代的1至30个碳原子的烷基或取代的烷基取代的烷基芳基；每个R2独立地表示具有2至60个碳原子和2至30个氧原子的基团，由以下公式表示：-（RO）k-H，其中R表示取代或未取代的烷基，k表示自然数2或更多。
• DYE FIXATIVE AGENTS AND METHODS
  申请人：Dow Global Technologies

  公开号：US20150210627A1

  公开（公告）日：2015-07-30

  Described are dye fixative agents, comprising an ether compound, including salts, of Formula I: wherein, R 1 is, independently at each occurrence, C1-C6 alkyl; R 2 and R 3 , are, independently at each occurrence, optionally substituted C6 alkyl; and X is, independently at each occurrence, CI, Br, or I.

  本文描述了染料固定剂，包括公式I中的醚化合物，包括盐，其中，R1在每次出现时独立地为C1-C6烷基；R2和R3在每次出现时独立地为可选取代的C6烷基；X在每次出现时独立地为CI，Br或I。

表征谱图