6-methoxy-2-pentylchroman-4-one | 1224712-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-methoxy-2-pentylchroman-4-one
• 英文别名: 6-Methoxy-2-pentyl-2,3-dihydrochromen-4-one
• CAS: 1224712-23-5
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: FLYJFPXPWQGLCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methoxy-2-pentylchroman-4-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以27.11%的产率得到6-methoxy-2-pentylchroman
  参考文献：
  名称：

  Design, synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents

  摘要：

  A series of 3-substituted quinazolinones, 2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in vitro. The new compounds revealed excellent in vitro antifungal activity with broad spectrum. The structure-activity relationships (SARs) of the derivatives were analyzed. Compound 9A2 exhibits better antifungal activity against 5 tested fungi in vitro than fluconazole, especially against Trichophyton rubrum and Microsporum gypseum. This study provides a series of novel lead compounds for the development of non-azole antifungal agents. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2015.04.030
• 作为产物：
  描述：

  2'-羟基-5'-甲氧基苯乙酮 、 正己醛 在 二异丙胺 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以26%的产率得到6-methoxy-2-pentylchroman-4-one
  参考文献：
  名称：

  KHMDS Enhanced SmI₂-Mediated Reformatsky Type α-Cyanation

  摘要：

  A novel combination of SmI2, KHMDS, and TsCN can be utilized to introduce a cyano group into structurally diverse and highly sensitive 2-alkyl-chroman-4-ones. Subsequent oxidation allows the formed 2-alkyl-3-cyanochromones to be isolated in yields ranging from 49 to 77%. In addition, alpha-bromoketones and esters were found to undergo equally effective alpha-cyanation.

  DOI：

  10.1021/ol100424y

文献信息

• Synthesis of Flavanone and Quinazolinone Derivatives from the Ruthenium-Catalyzed Deaminative Coupling Reaction of 2′-Hydroxyaryl Ketones and 2-Aminobenzamides with Simple Amines
  作者：Krishna Gnyawali、Pandula T. Kirinde Arachchige、Chae S. Yi

  DOI：10.1021/acs.orglett.1c03870

  日期：2022.1.14

  deaminative coupling reaction of 2′-hydroxyaryl ketones with simple amines to form 3-substituted flavanone products. The analogous deaminative coupling reaction of 2-aminobenzamides with branched amines directly formed 3,3-disubstituted quinazolinone products. The catalytic method efficiently installs synthetically useful flavanone and quinazolinone core structures without employing any reactive reagents.

  发现阳离子 Ru-H 配合物 [(C 6 H 6 )(PCy 3 )(CO)RuH] + BF 4 - ( 1 ) 与 3,4,5,6-四氯-1,2-苯醌 ( L1 )作为 2'-羟基芳基酮与简单胺的脱氨基偶联反应生成 3-取代黄烷酮产物的高效催化剂。2-氨基苯甲酰胺与支链胺的类似脱氨基偶联反应直接形成3,3-二取代喹唑啉酮产物。该催化方法有效地安装了合成有用的黄烷酮和喹唑啉酮核心结构，而无需使用任何反应性试剂。
• Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors
  作者：Maria Fridén-Saxin、Tina Seifert、Marie Rydén Landergren、Tiina Suuronen、Maija Lahtela-Kakkonen、Elina M. Jarho、Kristina Luthman

  DOI：10.1021/jm3005288

  日期：2012.8.23

  A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a one-step procedure including a base-mediated aldol condensation using microwave irradiation. The most potent compounds, with inhibitory concentrations in the low micromolar range, were substituted in the 2-, 6-, and 8-positions. Larger, electron-withdrawing substituents in the 6- and 8-positions were favorable. The most potent inhibitor of SIRT2 was 6,8-dibromo-2-pentylchroman-4-one with an IC50 of 1.5 mu M. The synthesized compounds show high selectivity toward SIRT2 over SIRT1 and SIRT3 and represent an important starting point for the development of novel SIRT2 inhibitors.
• Design, synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents
  作者：Hui Tang、Juan Wu、Wen Zhang、Lei Zhao、Ya-Hui Zhang、Cheng-Wu Shen

  DOI：10.1016/j.cclet.2015.04.030

  日期：2015.9

  A series of 3-substituted quinazolinones, 2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in vitro. The new compounds revealed excellent in vitro antifungal activity with broad spectrum. The structure-activity relationships (SARs) of the derivatives were analyzed. Compound 9A2 exhibits better antifungal activity against 5 tested fungi in vitro than fluconazole, especially against Trichophyton rubrum and Microsporum gypseum. This study provides a series of novel lead compounds for the development of non-azole antifungal agents. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
• KHMDS Enhanced SmI₂-Mediated Reformatsky Type α-Cyanation
  作者：Tobias Ankner、Maria Fridén-Saxin、Nils Pemberton、Tina Seifert、Morten Grøtli、Kristina Luthman、Göran Hilmersson

  DOI：10.1021/ol100424y

  日期：2010.5.21

  A novel combination of SmI2, KHMDS, and TsCN can be utilized to introduce a cyano group into structurally diverse and highly sensitive 2-alkyl-chroman-4-ones. Subsequent oxidation allows the formed 2-alkyl-3-cyanochromones to be isolated in yields ranging from 49 to 77%. In addition, alpha-bromoketones and esters were found to undergo equally effective alpha-cyanation.