5-(炔丙基氧基)-2'-脱氧尿苷 | 65367-85-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 中文名称: 5-(炔丙基氧基)-2'-脱氧尿苷
• 英文名称: 5-(propynyloxy)-2'-deoxyuridine
• 英文别名: 5-(2-propynyloxy)-2'-deoxyuridine；1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(prop-2-yn-1-yloxy)pyrimidine-2,4(1H,3H)-dione；5-prop-2-ynyloxy-2'-deoxy-uridine；Uridine, 2'-deoxy-5-(2-propynyloxy)-；1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-prop-2-ynoxypyrimidine-2,4-dione
• CAS: 65367-85-3
• 化学式: C₁₂H₁₄N₂O₆
• 分子量: 282.253
• InChiKey: GSTKQPVPFHMJNK-FXBDTBDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] METHOD OF CONJUGATING A POLYPEPTIDE<br/>[FR] MÉTHODE DE CONJUGAISON D'UN POLYPEPTIDE
  申请人：MEDIMMUNE LLC

  公开号：WO2016054315A1

  公开（公告）日：2016-04-07

  The present disclosure relates to a method of conjugating a compound of formula (I) O 5 R1-Q— (ZL-COn-X-N O (I) with a polypeptide comprising at least one thiol group and molecules obtained from said method.

  本公开涉及一种将化合物（I）O 5 R1-Q—（ZL-COn-X-NO（I）与至少含有一个硫醇基团的多肽共轭的方法，以及从该方法获得的分子。
• [EN] IDOXURIDINE AND ITS ANALOGS AS NEUROPROTECTANS FOR THE TREATMENT OF PARKINSONISM<br/>[FR] IDOXURIDINE ET SES ANALOGUES UTILISÉS COMME NEUROPROTECTEURS POUR LE TRAITEMENT DU PARKINSONISME
  申请人：SVENNINGSSON PER

  公开号：WO2018143893A1

  公开（公告）日：2018-08-09

  The invention relates to compounds that are useful in the treatment of parkinsonism, such as parkinsonism in connection with Parkinson's disease (PD); dementia with Lewy bodies (DLB); multiple system atrophy (MSA); corticobasal degeneration (CBD); or progressive supranuclear palsy (PSP). The said compounds include in particular idoxuridineand analogs thereofas well as their metabolic precursors, such as ropidoxuridine.The invention further relates to method for identifying compounds useful for the treatment of parkinsonism, said methods comprising detecting the capability of compound to increase the amount of GPR37 in cell membranes.The invention further relates to methods for the chemical synthesis of ropidoxuridine.

  本发明涉及一种在帕金森病（PD）相关的帕金森综合征，如帕金森病（PD）；具有Lewy小体的痴呆（DLB）；多系统萎缩（MSA）；皮质基底节变性（CBD）；或进行性核上性麻痹（PSP）等治疗中有用的化合物。所述化合物包括特别是碘沙宝嘌呤及其类似物以及它们的代谢前体，如罗匹沙宝嘌呤。本发明还涉及一种用于鉴定治疗帕金森综合征的有用化合物的方法，该方法包括检测化合物增加细胞膜中GPR37数量的能力。本发明还涉及罗匹沙宝嘌呤的化学合成方法。
• Dual labeling methods for measuring cellular proliferation
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10138510B2

  公开（公告）日：2018-11-27

  The present invention provides a method for measuring cellular nascent nucleic acid synthesis by dual pulse labeling of nucleic acid. The first pulse labeling of nucleic acid with a nucleoside analog allows establishment of a baseline nucleic acid synthesis rate. Pulse labeling of the nucleic acid with a second nucleoside analog then allows measurement of any changes to nucleic acid synthesis. The nucleic acid synthesis can be measured as cell proliferation, DNA, or gene expression, RNA. This method does not require a potentially artifact-inducing intermediary wash step between pulse labels. Additionally, this method may be used to screen compounds for their affect on cellular proliferation by treating cells or an organism with the test compound simultaneous to or before treatment with a competitive nucleoside analog.

  本发明提供了一种通过核酸双脉冲标记测量细胞新生核酸合成的方法。用核苷类似物对核酸进行第一次脉冲标记，可以确定核酸合成的基线速率。然后用第二种核苷类似物对核酸进行脉冲标记，以测量核酸合成的任何变化。核酸合成可以用细胞增殖（DNA）或基因表达（RNA）来测量。这种方法不需要在脉冲标记之间进行可能导致伪影的中间清洗步骤。此外，在用竞争性核苷类似物处理细胞或生物体的同时或之前，用测试化合物处理细胞或生物体，这种方法可用于筛选对细胞增殖有影响的化合物。
• DUAL LABELING METHODS FOR MEASURING CELLULAR PROLIFERATION
  申请人：Life Technologies Corporation

  公开号：EP2297344B1

  公开（公告）日：2018-03-14
• EP3200829A1
  申请人：——

  公开号：EP3200829A1

  公开（公告）日：2017-08-09