N-(2-pyridyl)-4,4-dimethyl pentanamide | 579470-27-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-pyridyl)-4,4-dimethyl pentanamide
• 英文别名: 4,4-dimethyl-N-pyridin-2-ylpentanamide
• CAS: 579470-27-2
• 化学式: C₁₂H₁₈N₂O
• 分子量: 206.288
• InChiKey: OZMNQFDKJLEMJV-UHFFFAOYSA-N

物化性质

• 沸点：
  373.1±15.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-pyridyl)-4,4-dimethyl pentanamide 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以97%的产率得到2,2-二甲基戊酸
  参考文献：
  名称：

  Ru-Catalyzed Hydroamidation of Alkenes and Cooperative Aminocarboxylation Procedure with Chelating Formamide

  摘要：

  A strategy of chelation-assisted activation of formamide was employed to achieve hydroamidation of alkenes to generate one-carbon-elongated amides in moderate to good selectivity and yields. Also reported is the two-metal-catalyzed cooperative aminocarboxylation of aryl iodides, in which Ru is presumed to catalyze decarbonylation of formamide to release carbon monoxide and amine for the subsequent Pd-catalyzed aminocarboxylation routes, thus enabling the net transformation to be performed in the absence of external CO pressure.

  DOI：

  10.1021/ol034862r
• 作为产物：
  描述：

  2-氨基吡啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 十二羰基三钌 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 6.0h， 生成 N-(2-pyridyl)-4,4-dimethyl pentanamide
  参考文献：
  名称：

  Ru-Catalyzed Hydroamidation of Alkenes and Cooperative Aminocarboxylation Procedure with Chelating Formamide

  摘要：

  A strategy of chelation-assisted activation of formamide was employed to achieve hydroamidation of alkenes to generate one-carbon-elongated amides in moderate to good selectivity and yields. Also reported is the two-metal-catalyzed cooperative aminocarboxylation of aryl iodides, in which Ru is presumed to catalyze decarbonylation of formamide to release carbon monoxide and amine for the subsequent Pd-catalyzed aminocarboxylation routes, thus enabling the net transformation to be performed in the absence of external CO pressure.

  DOI：

  10.1021/ol034862r

文献信息

• Inhibitors of Akt Activity
  申请人：Bilodeau Mark T.

  公开号：US20080280899A1

  公开（公告）日：2008-11-13

  The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及含有取代萘啶的化合物，其抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明还涉及包含该发明化合物的化疗组合物以及使用该发明化合物治疗癌症的方法。
• 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
  申请人：Grünenthal GmbH

  公开号：US10793528B2

  公开（公告）日：2020-10-06

  The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

  本发明涉及 3-(羧乙基)-8-氨基-2-氧代-1,3-二氮杂-螺-[4.5]-癸烷衍生物、其制备方法及其在医学中的应用，特别是在疼痛治疗中的应用。
• Substituted Azaspiro(4.5)Decane Derivatives
  申请人：Gruenenthal GmbH

  公开号：US20170210734A1

  公开（公告）日：2017-07-27

  The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
• 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
  申请人：Grünenthal GmbH

  公开号：US20200399226A1

  公开（公告）日：2020-12-24

  The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
• US7750151B2
  申请人：——

  公开号：US7750151B2

  公开（公告）日：2010-07-06