1-Brom-2-mercapto-naphthalin | 90767-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Brom-2-mercapto-naphthalin
• 英文别名: 1-Bromonaphthalene-2-thiol
• CAS: 90767-26-3
• 化学式: C₁₀H₇BrS
• 分子量: 239.136
• InChiKey: XQAQBOVYSSQDNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Brom-2-mercapto-naphthalin 、 5-溴噻唑烷-2,4-二酮 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以84%的产率得到5-<(1-bromo-2-naphthalenyl)thio>-2,4-thiazolidinedione
  参考文献：
  名称：

  Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones

  摘要：

  A series of 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones were synthesized and evaluated for antihyperglycemic activity in an insulin-resistant, genetically diabetic db/db mouse model of non-insulin-dependent diabetes mellitus (NIDDM). The sulfones could be synthesized by a novel, selective C-5 sulfonylation of dilithio-2,4-thiazolidinedione with appropriate sulfonyl chlorides. Within this series, naphthalene was found to be superior to other groups for eliciting antihyperglycemic activity, including the p-alkoxyphenyl group found in ciglitazone, a prototypical agent for this activity. Attachment of the 5-sulfonyl-2,4-thiazolidinedione moiety to the 2-naphthalene position led to optimum activity. Other linkers between the naphthalene and 2,4-thiazolidinedione rings, such as thio, methylene, oxy, and sulfinyl led to decreased antihyperglycemic activity. The best analogue, 5-(2-naphthalenylsulfonyl)-2,4-thiazolidinedione (AY-31,637) was equipotent to ciglitazone in two animal models of NIDDM.

  DOI：

  10.1021/jm00167a022

文献信息

• GOLF BALL
  申请人：Fushihara Kazuhisa

  公开号：US20120010021A1

  公开（公告）日：2012-01-12

  An object of the present invention is to provide a golf ball traveling a greater distance by improving the properties of the spherical core. The present invention provides a golf ball comprising a spherical core, and at least one cover layer covering the spherical core, wherein the spherical core is formed from a rubber composition containing a base rubber, a co-crosslinking agent, a crosslinking initiator, a filler and a polynuclear aromatic organic sulfur compound or a derivative thereof, and the spherical core has a specific hardness distribution without decreasing hardness from a central point toward a surface of the spherical core in JIS-C hardness.

  本发明的目的是通过改善球心的特性，提供一个能够飞行更远的高尔夫球。本发明提供了一种高尔夫球，包括一个球心和至少一层覆盖在球心上的外覆层，其中球心由一种橡胶组合物形成，该组合物包含基础橡胶、共交联剂、交联引发剂、填料和多核芳香有机硫化合物或其衍生物，并且球心在JIS-C硬度上具有特定的硬度分布，从球心中心向表面不降低硬度。
• TETRAZOLINONE COMPOUNDS AND ITS USE
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150031733A1

  公开（公告）日：2015-01-29

  The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein, R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, a C3-C12 cycloalkyl group or an adamantyl group, etc., which each optionally be substituted; R2 represents a hydrogen atom, an C1-C12 alkyl group, or a halogen atom, etc.; R4 and R5 represent independently of each other a hydrogen atom or an C1-C3 alkyl group, etc.; R6, R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, an C1-C12 alkyl group, a C1-C12 haloalkyl group, an C2-C12 alkenyl group, a C3-C12 cycloalkyl group, an C1-C12 alkoxy group or a C1-C12 haloalkoxy group, etc.; X and Y represent independently of each other a sulfur atom or an oxygen atom; Q represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

  本发明提供了一种具有优异的杀虫功效的化合物。公式（1）的四唑酮化合物：[其中，R1代表C6-C16芳基，C1-C12烷基，C3-C12环烷基或金刚烷基等，每个都可以选择性地被取代；R2代表氢原子，C1-C12烷基或卤素原子等；R4和R5分别独立地代表氢原子或C1-C3烷基等；R6、R7、R8和R9分别独立地代表氢原子、卤素原子、C1-C12烷基、C1-C12卤代烷基、C2-C12烯基、C3-C12环烷基、C1-C12烷氧基或C1-C12卤代烷氧基等；X和Y分别独立地代表硫原子或氧原子；Q代表氧原子或硫原子；R10代表C1-C6烷基等]在控制害虫方面表现出优异的效果。
• TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150051171A1

  公开（公告）日：2015-02-19

  The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

  本发明提供了一种具有优异的杀虫功效的化合物。公式（1）的四唑烷酮化合物：[其中，R1代表C6-C16芳基，C1-C12烷基或C3-C12环烷基等，每个都可以选择性地被取代；R2、R3、R4和R5分别独立地表示氢原子、卤素原子或C1-C3烷基等；R6表示C1-C6烷基，C3-C6环烷基，卤素原子，C1-C6卤代烷基，C2-C6烯基，C1-C6烷氧基或C1-C6卤代烷氧基等；R7、R8和R9独立地表示氢原子、卤素原子或C1-C4烷基等；X表示氧原子或硫原子；R10表示C1-C6烷基等]对害虫具有优异的控制功效。
• Golf ball
  申请人：Dunlop Sports Co., Ltd.

  公开号：EP2537887A2

  公开（公告）日：2012-12-26

  An object of the present invention is to provide a golf ball showing a great flight distance on driver shots. The present invention provides a golf ball comprising a spherical core and at least one cover layer covering the spherical core, wherein the spherical core is formed from a rubber composition containing (a) base rubber, (b) an α,β-unsaturated carboxylic acid having 3 to 8 carbon atoms and/or a metal salt thereof as a co-crosslinking agent, (c) a crosslinking initiator and (d) a carboxylic acid having 1 to 14 carbon atoms, provided that the rubber composition further contains (e) a metal compound in case of containing only (b) the α,β-unsaturated carboxylic acid having 3 to 8 carbon atoms as the co-crosslinking agent.

  本发明的目的是提供一种在发球木杆击球时飞行距离远的高尔夫球。本发明提供了一种高尔夫球，包括一个球形芯和至少一个覆盖在球形芯上的覆盖层，其中球形芯由橡胶组合物形成，该橡胶组合物含有(a)基础橡胶，(b)具有 3 至 8 个碳原子的α，β-不饱和羧酸和/或作为共交联剂的金属盐，(c)交联引发剂和(d)具有 1 至 14 个碳原子的羧酸、(c) 交联引发剂和 (d) 具有 1 至 14 个碳原子的羧酸，条件是在仅含有 (b) 具有 3 至 8 个碳原子的 α，β-不饱和羧酸作为共交联剂的情况下，橡胶组合物还含有 (e) 金属化合物。
• [EN] NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES<br/>[FR] NOUVEAUX MULTIMÈRES LIÉS AU POLYMÈRE MONOPHOSPHATE DE GUANOSINE-3', 5'-CYCLIQUES
  申请人：MIRECA MEDICINES GMBH

  公开号：WO2018041942A9

  公开（公告）日：2019-01-17