2-Methyldibenzothiophen-5,5-dioxid | 20928-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-Methyldibenzothiophen-5,5-dioxid
• 英文别名: 2-methyl-dibenzothiophene-5,5-dioxide；Dibenzothiophene, 2-methyl-, 5,5-dioxide；2-methyldibenzothiophene 5,5-dioxide
• CAS: 20928-03-4
• 化学式: C₁₃H₁₀O₂S
• 分子量: 230.287
• InChiKey: HXKYZSSOMYZAAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-methyldibenzothiophene 在 双氧水 、 溶剂黄146 作用下， 生成 2-Methyldibenzothiophen-5,5-dioxid
  参考文献：
  名称：

  Synthesis of Some Dibenzothiophene Derivatives

  摘要：

  DOI：

  10.1021/jo01356a014

文献信息

• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20180076396A1

  公开（公告）日：2018-03-15

  A condensed cyclic compound having the following structure and an organic light-emitting device including the same are provided: wherein A1 is one of the following:

  提供具有以下结构的缩合环化合物以及包括该化合物的有机发光器件：其中A1是以下之一：
• CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF
  申请人：INABA Takashi

  公开号：US20080261994A1

  公开（公告）日：2008-10-23

  The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R 1 is —(CH 2 ) m —X—(CH 2 ) n -A 1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A 1 is a substituted C 3-14 hydrocarbon ring group, etc.; R 2 and R 3 are the same or different and each is a hydrogen atom, —(CH 2 ) p —X 1 —(CH 2 ) q -A 2 , etc., wherein p and q are the same or different and each is 0 to 6, X 1 is a single bond, etc. and A 2 is an optionally substituted C 3-14 hydrocarbon ring group, etc.; R 4 is —CO 2 R 9 , etc., wherein R 9 is a hydrogen atom, etc.; and R 20 and R 21 are the same or different and each is a hydrogen atom, —(CH 2 ) m12 —X 12 —(CH 2 ) m12 —R 30 , etc., wherein m12 and m12 are the same or different and each is 0 to 6, X 12 is a single bond, etc. and R 30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有抑制aggrecanase和MMP-13活性的化合物，可用作治疗骨关节炎，类风湿性关节炎等疾病的治疗剂，更具体地说，是式（1）的环丙烷化合物：其中，R1为—（CH2）m—X—（ ）n-A1等，其中m和n相同或不同，每个为0至6，X为单键等，A1为取代的C3-14烃环基等；R2和R3相同或不同，每个为氢原子，—（ ）p—X1—（ ）q-A2等，其中p和q相同或不同，每个为0至6，X1为单键等，A2为可选取代的C3-14烃环基等；R4为—CO2R9等，其中R9为氢原子等；以及R20和R21相同或不同，每个为氢原子，—（ ）m12—X12—（ ）m12—R30等，其中m12和m12相同或不同，每个为0至6，X12为单键等，R30为氢原子等；或其前药或其药学上可接受的盐。
• Cyclopropane compounds and pharmaceutical use thereof
  申请人：Inaba Takashi

  公开号：US20100105894A1

  公开（公告）日：2010-04-29

  The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R 1 is —(CH 2 ) m —X—(CH 2 ) n -A 1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A 1 is a substituted C 3-14 hydrocarbon ring group, etc.; R 2 and R 3 are the same or different and each is a hydrogen atom, —(CH 2 ) p —X 1 —(CH 2 ) q -A 2 , etc., wherein p and q are the same or different and each is 0 to 6, X 1 is a single bond, etc. and A 2 is an optionally substituted C 3-14 hydrocarbon ring group, etc.; R 4 is —CO 2 R 9 , etc., wherein R 9 is a hydrogen atom, etc.; and R 20 and R 21 are the same or different and each is a hydrogen atom, —(CH 2 ) m12 —X 12 —(CH 2 ) m12 —R 30 , etc., wherein m12 and m12 are the same or different and each is 0 to 6, X 12 is a single bond, etc. and R 30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有聚集素酶抑制活性和MMP-13抑制活性的化合物，可用作治疗骨关节炎、类风湿性关节炎等疾病的治疗剂，更具体地说，是式（1）的环丙烷化合物：其中R1为—（CH2）m—X—（ ）n-A1等，其中m和n相同或不同，每个为0到6，X为单键等，A1为取代的C3-14碳氢环基等；R2和R3相同或不同，每个为氢原子，—（ ）p—X1—（ ）q-A2等，其中p和q相同或不同，每个为0到6，X1为单键等，A2为可选取代的C3-14碳氢环基等；R4为—CO2R9等，其中R9为氢原子等；以及R20和R21相同或不同，每个为氢原子，—（ ）m12—X12—（ ）m12—R30等，其中m12和m12相同或不同，每个为0到6，X12为单键等，R30为氢原子等；或其前体药物或其药学上可接受的盐。
• Condensed cyclic compound and organic light-emitting device including the same
  申请人：Samsung Display Co., Ltd.

  公开号：US10461263B2

  公开（公告）日：2019-10-29

  A condensed cyclic compound having the following structure and an organic light-emitting device including the same are provided: wherein A1 is one of the following:

  本发明提供了一种具有以下结构的缩合环状化合物和一种包含该化合物的有机发光器件： 其中 A1 为下列物质之一：
• Compound, preparation method thereof and organic light emitting display device
  申请人：SHANGHAI TIANMA AM-OLED CO., LTD.

  公开号：US10759802B2

  公开（公告）日：2020-09-01

  The present disclosure relates to the field of technology of an OLED material and a device having the same, and particularly to a compound, a preparation method thereof and an organic light emitting display device, wherein the compound has a structure expressed by formula (I).

  本公开涉及有机发光二极管材料及其器件的技术领域，特别是涉及一种化合物、其制备方法和一种有机发光显示器件，其中化合物具有式（I）表示的结构。