1-(2-chloro-prop-2-enyl)-piperidine | 59352-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-chloro-prop-2-enyl)-piperidine
• 英文别名: 1-(2-chloro-allyl)-piperidine；1-(2-Chlor-allyl)-piperidin；1-(2-Chloroprop-2-enyl)piperidine
• CAS: 59352-40-8
• 化学式: C₈H₁₄ClN
• mdl: MFCD13179065
• 分子量: 159.659
• InChiKey: HEWGDHWRYMOQFY-UHFFFAOYSA-N

物化性质

• 沸点：
  70-71 °C(Press: 10 Torr)
• 密度：
  0.9969 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-chloro-prop-2-enyl)-piperidine 在 氢氟酸 、 五氟化锑 作用下， 反应 0.17h， 以64%的产率得到1-(2,2-difluoropropyl)piperidine
  参考文献：
  名称：

  Selective Synthesis of gem-Chlorofluorinated Nitrogen-Containing Derivatives after Superelectrophilic Activation in Superacid HF/SbF₅

  摘要：

  The first direct selective synthesis of novel gem-chloro-fluorinated nitrogen-containing building blocks in super-acid is reported. The dramatic role of the chlorine atom on the reaction is shown by in situ NMR experiments and allows the involvement of a novel original superelectrophilic activation process in superacid HF/SbF5 to be postulated.

  DOI：

  10.1021/jo102225w
• 作为产物：
  描述：

  哌啶 、 2,3-二氯丙烯 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以77%的产率得到1-(2-chloro-prop-2-enyl)-piperidine
  参考文献：
  名称：

  Weakly ligated palladium complexes PdCl2(RCN)2 in piperidine: versatile catalysts for Sonogashira reaction of vinyl chlorides at room temperature

  摘要：

  Copper iodide and weakly ligated palladium complexes PdCl2(RCN)(2) (R = Ph, Me) catalyzed efficiently the coupling reaction of vinyl chlorides with 1-alkynes in the presence of piperidine to give the corresponding conjugated enynes in good to excellent yields. The reaction takes place rapidly and cleanly at room temperature. Application to the synthesis of terbinafine which exhibits strong antimycotic activity has been realized. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(00)00909-8

文献信息

• Preparation and Polymerization of Unsaturated Quaternary Ammonium Compounds. II. Halogenated Allyl Derivatives^1,2
  作者：George B. Butler、Francis L. Ingley

  DOI：10.1021/ja01147a003

  日期：1951.3
• KURGINYAN K. A.; ARAKELOVA S. V.; KALAJDZHYAN A. E., ARM. XIM. ZH., 39,(1986) N 8, 516-526
  作者：KURGINYAN K. A.、 ARAKELOVA S. V.、 KALAJDZHYAN A. E.

  DOI：——

  日期：——
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• US5731435A
  申请人：——

  公开号：US5731435A

  公开（公告）日：1998-03-24
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.