2-(N,N-dimethylamino)-1-methyl-1H-imidazole | 138040-03-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(N,N-dimethylamino)-1-methyl-1H-imidazole
• 英文别名: 2-dimethylamino-1-methylimidazole；N,N,1-Trimethyl-1H-imidazol-2-amine；N,N,1-trimethylimidazol-2-amine
• CAS: 138040-03-6
• 化学式: C₆H₁₁N₃
• 分子量: 125.173
• InChiKey: OZMHRFCCTJGGCL-UHFFFAOYSA-N

物化性质

• 沸点：
  201.8±23.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(N,N-dimethylamino)-1-methyl-1H-imidazole 在 吡啶 、 三乙胺 、 三氯化磷 作用下， 反应 30.0h， 以66%的产率得到tris[2-(dimethylamino)-1-methyl-1H-imidazol-5-yl]phosphine
  参考文献：
  名称：

  5-磷酸化 1,2-二取代咪唑

  摘要：

  1,2-二取代咪唑与吡啶中的卤化磷(III)在5位发生区域选择性反应。反应越容易进行，起始咪唑中2-取代基的给电子能力越高。迄今未知的二卤（咪唑-5-基）膦已经获得，并且已经研究了它们的性质。还开发了用于制备各种单卤（有机基）（咪唑基）膦的合成方法。© 2009 Wiley Periodicals, Inc. 杂原子化学 20:289–308, 2009; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20550

  DOI：

  10.1002/hc.20550

文献信息

• N-Phosphorylated Imidazolium Salts as Precursors to 2- and 5-Phosphorylated Imidazoles and New Imidazol-2-ylidenes Featuring the PNCN Unit
  作者：Anatolii P. Marchenko、Heorgii N. Koidan、Anastasiya N. Huryeva、Evgeniy V. Zarudnitskii、Aleksandr A. Yurchenko、Aleksandr N. Kostyuk

  DOI：10.1021/jo101177h

  日期：2010.11.5

  It has been experimentally proven that the reaction of 1- or 1,2-disubstituted imidazoles with diorganylphosphorus(III) halides proceeds via initial formation of N-phosporylated imidazolium salts. Treatment of these salts with strong bases results in phosphorylation of the parent imidazoles at the 2- or 5-positions, correspondingly. In a previous case, imidazol-2-ylidenes are formed as intermediates

  实验已经证明1-或1，2-二取代的咪唑与二有机基磷（III）卤化物的反应是通过最初形成N-磷酸化的咪唑鎓盐而进行的。用强碱处理这些盐会相应地导致母体咪唑在2或5位发生磷酸化。在先前的情况下，形成咪唑-2-亚基作为中间体。在N1和N3原子上都带有空间要求或/和π供体基团的情况下，将1,3-二取代的咪唑鎓盐与NaN（SiMe 3）2进行去质子化反应可得到新的稳定的N-磷取代的Arduengo型卡宾。
• RUBBER COMPOSITION, AND PNEUMATIC TIRE USING SAME
  申请人：YUKIMURA Noriaki

  公开号：US20150361248A1

  公开（公告）日：2015-12-17

  The invention provides a rubber composition prepared by mixing, per 100 parts by mass of a rubber component comprising at least 50% by mass of a diene-based rubber, from 20 to 150 parts by mass of a filler, and from 0.05 to 30 parts by mass of a compound A which has a specific guanidine structure and has a functional group reactive with the diene-based rubber. The rubber composition improves both a high elastic modulus and a low tan δ. The invention also provides a pneumatic tire using the rubber composition.

  本发明提供了一种橡胶组合物，其中包括：100份质量份的橡胶组分，至少包括50份质量份的二烯基橡胶；20至150份质量份的填料；以及0.05至30份质量份的化合物A，其具有特定的胍基结构并具有与二烯基橡胶反应的功能性基团。该橡胶组合物提高了高弹性模量和低tanδ。本发明还提供了使用该橡胶组合物的充气轮胎。
• Synthesis of 2-dimethylaminoimidazole derivatives: a new access to indolyl-imidazole alkaloids of marine origin.
  作者：Angeliki Dalkafouki、Janick Ardisson、Nicole Kunesch、Liliane Lacombe、Jacques E. Poisson

  DOI：10.1016/s0040-4039(00)92376-1

  日期：1991.9

  The first preparation of 2-dimethylaminoimidazole 1a, a structural feature of several marine products was undertaken and its reactivity investigated. The synthesis of natural alkaloids 5 and 12b was achieved by direct coupling of the easily accessible oxidized 2-dimethylaminoimidazoles 7 and 8 with indole-3-carboxaldehyde and indole respectively, demonstrating the usefulness of this approach for other structurally related natural products.
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES
  申请人：Reiser Jochen

  公开号：US20100297139A1

  公开（公告）日：2010-11-25

  The present invention is directed to methods of treating proteinuric diseases by the administration of avβ3 integrin inhibitors.
• Methods and Compositions for the Treatment of Proteinuric Diseases
  申请人：The General Hospital Corporation

  公开号：US20160296592A1

  公开（公告）日：2016-10-13

  The present invention is directed to methods of treating proteinuric diseases by the administration of avβ3 integrin inhibitors.