(S)-2-trimethylsilyloxyoctane | 65500-76-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (S)-2-trimethylsilyloxyoctane
• 英文别名: trimethyl-((S)-1-methyl-heptyloxy)-silane；(S)-2-trimethylsilanyloxy-octane；(+)-(S)-2-(Trimethylsilyloxy)octan；d-S-2-Octyltrimethylsilylether；Trimethyl{[(2S)-octan-2-yl]oxy}silane；trimethyl-[(2S)-octan-2-yl]oxysilane
• CAS: 65500-76-7
• 化学式: C₁₁H₂₆OSi
• 分子量: 202.412
• InChiKey: UHWVCRDNNJCGLG-NSHDSACASA-N

物化性质

• 沸点：
  208.9±8.0 °C(Predicted)
• 密度：
  0.801±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (S)-2-trimethylsilyloxyoctane 在 碘代三甲硅烷 作用下， 以 氯仿 为溶剂， 生成 (R)-(-)-2-iodooctane
  参考文献：
  名称：

  通过三甲基甲硅烷基碘处理将醇有效转化为碘化物的新方法

  摘要：

  DOI：

  10.1016/s0040-4039(01)83039-2
• 作为产物：
  描述：

  (S)-(+)-2-辛醇 、 三甲基硅咪唑 以 乙醚 为溶剂， 生成 (S)-2-trimethylsilyloxyoctane
  参考文献：
  名称：

  Maximum optical rotation of 2-fluorooctane? A survey of fluorinating reagents

  摘要：

  DOI：

  10.1021/jo01333a030

文献信息

• Ionic liquid facilitates biocatalytic conversion of hardly water soluble ketones
  作者：Christina Kohlmann、Nora Robertz、Susanne Leuchs、Zübeyde Dogan、Stephan Lütz、Katrin Bitzer、Shukrallah Na’amnieh、Lasse Greiner

  DOI：10.1016/j.molcatb.2010.10.003

  日期：2011.2

  Ionic liquids represent a promising alternative to conventional cosolvents as biocompatible solubilisers for biocatalysis. This was shown using water miscible ionic liquids to facilitate the stereoselective reduction of hardly water soluble, aliphatic ketones catalysed by the alcohol dehydrogenase from Lactobacillus brevis. Ten ionic liquids were screened for activity and solubility. Improved storage stabilities besides improved enzyme activities, as well as reduced substrate surplus and product inhibitions were found, while applying the most promising AMMOENG (TM) 101 in more detailed investigations. Batch reactions with cofactor regeneration via a glucose dehydrogenase showed increased reaction rates; thus underlining the positive influence of AMMOENG (TM) 101. For (R)-3-octanol, (R)-2-nonanol, (R)-2-decanol, and (R)-2-octanol space time yields between 250 and 350 mmol L-1 d(-1) were achieved. (c) 2010 Elsevier B.V. All rights reserved.
• A one-step and chemoselective conversion of silyl-protected alcohols into the corresponding acetates
  作者：Takeshi Oriyama、Mihoko Oda、Junko Gono、Gen Koga

  DOI：10.1016/s0040-4039(00)73040-1

  日期：1994.3

  A reagent system of acetyl bromide combined with a catalytic amount of tin(II) bromide cleaves readily trialkylsilyl ethers to give the corresponding acetates in high yields under very mild conditions.
• Oriyama Takeshi, Oda Mihoko, Gono Junko, Koga Gen, Tetrahedron Lett, 35 (1994) N 13, S 2027-2030
  作者：Oriyama Takeshi, Oda Mihoko, Gono Junko, Koga Gen

  DOI：——

  日期：——
• A new method for the efficient conversion of alcohols into iodides via treatment with trimethylsilyl iodide
  作者：Michael E. Jung、Paul L. Ornstein

  DOI：10.1016/s0040-4039(01)83039-2

  日期：1977.1
• Maximum optical rotation of 2-fluorooctane? A survey of fluorinating reagents
  作者：Jacques Leroy、Eric Hebert、Claude Wakselman

  DOI：10.1021/jo01333a030

  日期：1979.9