1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamide | 76462-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamide
• 英文别名: 1,4-dioxo-3,4-dihydro-1H-phthalazine-2-carboxylic acid amide；1,4-Dioxo-3,4-dihydro-1H-phthalazin-2-carbonsaeure-amid；1,4-dioxo-3H-phthalazine-2-carboxamide
• CAS: 76462-35-6
• 化学式: C₉H₇N₃O₃
• 分子量: 205.173
• InChiKey: KKUZIYJFSPWYTB-UHFFFAOYSA-N

物化性质

• 熔点：
  257-259 °C
• 密度：
  1.522±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯酐 、 S-(4-叔-丁基苯甲基)[2-(1-甲基丁基)吡啶-3-基]硫代氨基甲酸酯 在 montmorillonite K₁₀ 作用下， 反应 0.35h， 以78%的产率得到1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamide
  参考文献：
  名称：

  Solvent-free Synthesis of Phthalazine-2(1H)-carboxamide Derivatives Using K-10 Clay Under Microwave Irradiation

  摘要：

  蒙脱石 K-10 粘土可在微波辐照下催化不同酸酐与半卡巴肼的反应。相应的羧酰胺衍生物收率高、反应时间短。

  DOI：

  10.2174/1570178611310050009

文献信息

• Synthesis and biological activity evaluation of differently substituted 1,4-dioxo-3,4-dihydrophthalazine-2(1<i>H</i>)-carboxamides and -carbothioamides
  作者：M. C. Cardia、S. Distinto、E. Maccioni、L. Bonsignore、A. Delogu

  DOI：10.1002/jhet.5570400609

  日期：2003.11

  Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides or 1,4-dioxo-3,4-dihydrophthal-azine-2(1H)-carbothioamides under mild conditions and generally with good yields. These compounds have been tested in order to evaluate their anti-microbial activity. Furthermore a new synthetic pathway

  不同取代的邻苯二甲酸酐可以与氨基脲或硫代氨基脲反应，分别得到1,4-二氧代-3,4-二氢邻苯二甲酸-2（1 H）-羧酰胺或1,4-二氧代-3,4-二氢邻苯二甲酸-2（ 1 H）-碳硫代酰胺在温和的条件下且通常收率良好。这些化合物已经过测试，以评估其抗微生物活性。此外，已设计出一种新的合成途径，用于合成邻苯二酚[2,3 - b ]邻苯二甲酰5,7,12,14-四酮。
• Desai, A. C.; Desai, C. M., Journal of the Indian Chemical Society, 1980, vol. 57, # 7, p. 757 - 758
  作者：Desai, A. C.、Desai, C. M.

  DOI：——

  日期：——
• DESAI A. C.; DESAI C. M., J. INDIAN CHEM. SOC., 1980, 57, NO 7, 757-758
  作者：DESAI A. C.、 DESAI C. M.

  DOI：——

  日期：——
• [EN] GREEN TECHNOLOGY LINE FOR PRODUCTION OF CLAY MICRO- AND NANOPARTICLES AND THEIR FUNCTIONAL POLYMER NANOHYBRIDS FOR NANOENGINEERING AND NANOMEDICINE APPLICATIONS<br/>[FR] CHAÎNE DE FABRICATION DE TECHNOLOGIE VERTE DE MICRO- ET NANOPARTICULES D'ARGILE ET DE LEURS NANOHYBRIDES POLYMÈRES FONCTIONNELS POUR APPLICATIONS DE NANO-INGÉNIÉRIE ET DE NANO-MÉDECINE
  申请人：RZAYEV ZAKIR

  公开号：WO2014021800A2

  公开（公告）日：2014-02-06

  Green technology method is described a combination of prototype processing for the preparation, purification and modification of micro- and nano-size scale clay particles from mineral resources of Turkey using novel functional organic intercalants as reactive nanofillers, alternating copolymers of maleic anhydride and their grafts with biopolymers as reactive compatibilizers and bioactive matrix polymers, thermoplastics, thermosets and rubbers as processible matrix polymers, which are useful for preparation of novel high performance engineering and bioengineering polymer layered silicate nanomaterials (nanofims, nanocoatings, nanofibers, nanomedicals and etc.).
• Solvent-free Synthesis of Phthalazine-2(1H)-carboxamide Derivatives Using K-10 Clay Under Microwave Irradiation
  作者：Omid Marvi、Mohammad Nikpasand

  DOI：10.2174/1570178611310050009

  日期：2013.5.1

  Montmorillonite K-10 clay catalyzes the reaction of different anhydrides with semicarbazide under microwave irradiation. The corresponding carboxamide derivatives are obtained in high yield and short reaction times.

  蒙脱石 K-10 粘土可在微波辐照下催化不同酸酐与半卡巴肼的反应。相应的羧酰胺衍生物收率高、反应时间短。