hexaisopropylphosphorous triamide | 59758-27-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hexaisopropylphosphorous triamide
• 英文别名: hexaisopropyltriamidophosphite；tris(diisopropylamino)phosphine；N-bis[di(propan-2-yl)amino]phosphanyl-N-propan-2-ylpropan-2-amine
• CAS: 59758-27-9
• 化学式: C₁₈H₄₂N₃P
• 分子量: 331.525
• InChiKey: ZXRILBDKWGKAGF-UHFFFAOYSA-N

物化性质

• 沸点：
  357.5±11.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  hexaisopropylphosphorous triamide 在 sulfur 作用下， 以 乙腈 为溶剂， 反应 1.83h， 生成 1,7-bis(tetraisopropyldiaminothiophosphoryloxy)naphthalene
  参考文献：
  名称：

  Cyclobisphosphorylation of 1,7-Dihydroxynaphthalene with Phosphorous Triamides

  摘要：

  Cyclobisphosphorylation of dihydroxynaphthalenes was studied with the aim to prepare organophosphorus aromatic compounds containing intramolecular cavities. The design and the structural and chemical features of cyclobisphosphites prepared from unsymmetrical 1,7-dihydroxynaphthalene are considered. New data are reported on regioselective cyclophosphorylation of 1,7-dihydroxynaphthalene by disproportionation of its bis(diamidophosphorylated) derivatives.

  DOI：

  10.1023/b:rugc.0000025169.12605.2e
• 作为产物：
  描述：

  二异丙胺 在 三乙胺 、 三氯化磷 作用下， 以 苯 为溶剂， 反应 24.0h， 以42%的产率得到hexaisopropylphosphorous triamide
  参考文献：
  名称：

  摘要：

  Reaction of resorcinol with phosphorous triamides containing various aliphatic radicals was studied. The preferential cleavage from phosphorus of the diisopropylamino group compared with the less bulky dimethylamino group was observed for the first time. It was shown that resorcinol is easily phosphorylated under mild conditions independent of the nature of substituent on nitrogen, but sterically hindered bulky radicals on nitrogen slow down phenolysis not only of the first, but also of the second amido group.

  DOI：

  10.1023/a:1020807208325

文献信息

• BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20160340374A1

  公开（公告）日：2016-11-24

  An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound. The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R 1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R 2 to R 4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z + represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)

  本发明的目的是提供一种化合物，能够在与碱反应性化合物混合状态长时间存储的情况下，仍能获得具有高储存稳定性的组合物，而不与碱反应性化合物发生反应，同时还能通过光照（活性能量射线）或加热产生强碱（胍胺、双胍胺、磷氮烷或磷銨）；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。本发明涉及由通式（A）表示的化合物；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。（其中R1代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；烯基；2-呋喃基炔基；2-噻吩基炔基；或2,6-二硫基基；R2到R4各自独立地代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基；呋喃基；噻吩基；或N-烷基取代的吡咯基；Z+代表具有胍胺基团、双胍胺基团或磷氮烷基团的铵阳离子，或磷銨阳离子。）
• 一种亚磷酰化试剂及其在寡核苷酸合成中的应用
  申请人：广州同隽医药科技有限公司

  公开号：CN111039977B

  公开（公告）日：2022-11-08

  本发明提供一种亚磷酰化试剂将其应用，该亚磷酰化试剂为2‑腈基乙氧基上有大非极性取代基团的2‑腈基乙氧基亚磷酰胺类化合物，该亚磷酰化试剂能与核苷单体或核苷酸片段3′‑OH或5′‑OH反应生成亚磷酰二酯，亚磷酰二酯在合适的活化剂作用下与另一组核苷单体或核苷酸片段3′‑OH或5′‑OH继续反应生成亚磷酰三酯，经过氧化或硫化得到磷酸三酯或硫代磷酸三酯，去保护得到寡核苷酸，整个过程中所有亚磷酸酯中间体或磷酸酯中间体易溶于中低极性的溶剂，在高极性溶剂中溶解度却很低，而其它的反应原料或副产物却易溶于高极性溶剂，因而能通过非极性/极性溶剂萃取进行纯化，使得后续的链增长反应不受阻碍，既适用于逐个核苷酸接入也适用于片段法接入的反应。
• Cyclo[bis(1,7-naphthylenedialkylamidophosphites)]
  作者：Eduard E. Nifantyev、Elena N. Rasadkina、Yuliya B. Evdokimova、Adam I. Stash、Vitaly K. Belsky、Larisa K. Vasyanina

  DOI：10.1002/hc.10143

  日期：——

  The possibility of regioselective cyclobisphosphorylation of nonsymmetrical bisphenols was shown for the 1,7-dihydroxynaphthalene–phosphorous acid triamide system. The structure and essential chemical properties of the first nonsymmetrical phosphacyclophane were studied. New data demonstrating peculiar features of bisphenol diamidophosphites were obtained. © 2003 Wiley Periodicals, Inc. Heteroatom

  1,7-二羟基萘-亚磷酸三酰胺体系显示了非对称双酚区域选择性环双磷酸化的可能性。研究了第一种非对称磷环芳烷的结构和基本化学性质。获得了证明双酚二酰胺亚磷酸酯特殊特征的新数据。© 2003 Wiley Periodicals, Inc. 杂原子化学 14:404–412, 2003; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.10143
• Phosphorylation of aromatic diols with phosphorous acid triamides with bulky substituents
  作者：P. V. Slitikov、E. N. Rasadkina、L. K. Vasyanina、I. I. Levina、E. E. Nifant’ev

  DOI：10.1134/s1070363214030165

  日期：2014.3

  Phosphorylation of naphthodiols with hexaisopropyl- and hexabutyltriamides of phosphorous acid was studied for the first time. The features of these reactions were considered. A comparative analysis of the properties of the synthesized naphthophosphacyclophanes and dismutation of bisamidophosphites was performed.

  首次研究了萘二醇与亚磷酸的六异丙基-和六丁基三酰胺的磷酸化。考虑了这些反应的特征。进行了合成的萘磷杂环环烷和双酰胺基亚磷酸酯歧化的性质的比较分析。
• Synthesis and reactivity of [(R1R2N)2PH]Fe(CO)4 complexes. X-ray crystal structure of [(Ph2N)2PH]Fe(CO)4
  作者：Jean-Jacques Brunet、Remi Chauvin、Ousmane Diallo、Bruno Donnadieu、Joëlle Jaffart、Denis Neibecker

  DOI：10.1016/s0022-328x(98)00744-x

  日期：1998.11

  KHFe(CO)4 reacts with tris(amino)phosphines by substitution at phosphorus leading to [bis(amino)phosphine]tetracarbonyliron complexes [(R1R2N)2PH]Fe(CO)4. The X-ray structure has been determined for R1=R2=Ph. Deprotonation of these complexes with KH affords stable potassium phosphidotetracarbonylferrates which can be alkylated or acylated at phosphorus.

  KHFe（CO）4通过在磷处取代而与三（氨基）膦反应，生成[双（氨基）膦]四羰基铁配合物[（R 1 R 2 N）2 PH] Fe（CO）4。已经针对R 1＝ R 2＝ Ph确定了X射线结构。用KH使这些配合物去质子化，得到稳定的磷酸四羰基高铁酸钾，其可在磷处被烷基化或酰化。