2-(4-fluorophenyl)-N-(2-hydroxy-5-nitro-phenyl)acetamide | 931412-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(4-fluorophenyl)-N-(2-hydroxy-5-nitro-phenyl)acetamide
• 英文别名: 2-(4-fluorophenyl)-N-(2-hydroxy-5-nitrophenyl)acetamide
• CAS: 931412-47-4
• 化学式: C₁₄H₁₁FN₂O₄
• 分子量: 290.251
• InChiKey: XTHPMHOEVOMXNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-N-(2-hydroxy-5-nitro-phenyl)acetamide 在 nickel dichloride 、 锌 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以46%的产率得到N-(5-amino-2-hydroxy-phenyl)-2-(4-fluorophenyl)acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents

  摘要：

  A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (la-In, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolates. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 mu g/ml. Benzamide derivative Id exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 mu g/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.12.035
• 作为产物：
  描述：

  4-氟苯乙酸 在 氯化亚砜 、 碳酸氢钠 作用下， 以 乙醚 、 水 、 苯 为溶剂， 反应 3.0h， 生成 2-(4-fluorophenyl)-N-(2-hydroxy-5-nitro-phenyl)acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents

  摘要：

  A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (la-In, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolates. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 mu g/ml. Benzamide derivative Id exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 mu g/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.12.035

文献信息

• Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents
  作者：Tugba Ertan、Ilkay Yildiz、Semiha Ozkan、Ozlem Temiz-Arpaci、Fatma Kaynak、Ismail Yalcin、Esin Aki-Sener、Ufuk Abbasoglu

  DOI：10.1016/j.bmc.2006.12.035

  日期：2007.3

  A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (la-In, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolates. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 mu g/ml. Benzamide derivative Id exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 mu g/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. (c) 2007 Elsevier Ltd. All rights reserved.