(1,2,3,4,-tetrahydro-1-naphthyl)acetone | 59175-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1,2,3,4,-tetrahydro-1-naphthyl)acetone
• 英文别名: 1-(1,2,3,4-tetrahydronaphthalen-1-yl)propan-2-one；(1,2,3,4-Tetrahydro-[1]naphthyl)-aceton
• CAS: 59175-42-7
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: JRHRLCGEHYWREQ-UHFFFAOYSA-N

物化性质

• 沸点：
  127-129 °C(Press: 1 Torr)
• 密度：
  1.004±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1,2,3,4,-tetrahydro-1-naphthyl)acetone 、 苄胺 在 sodium tetrahydroborate 作用下， 以 甲醇 、 苯 为溶剂， 反应 3.0h， 以54%的产率得到N-benzyl-2-(1,2,3,4-tetrahydro-1-naphthyl)-1-methylethylamine
  参考文献：
  名称：

  Synthesis and antiulcer activity of (isochroman-1-yl)alkylamines. II.

  摘要：

  我们准备了多种N-苯乙基-2-(异香豆烷-1-基)-1-甲基乙胺（3b）的类似物，之前发现其对阿司匹林诱导的溃疡具有抑制活性，并且没有胃抗分泌活性。我们对这些类似物进行了胃抗分泌活性和对阿司匹林诱导溃疡的抑制活性检测。研究发现，抗溃疡活性需要一个碱性胺基团。将3b的异香豆烷环替换为硫异香豆烷、香豆烷或四氢萘环，导致抗溃疡活性的显著变化。在这些类似物中，香豆烷类似物N-苯乙基-2-(香豆烷-4-基)-1-甲基乙胺（32b）显示出最强的抗溃疡活性，效果与3b相当。

  DOI：

  10.1248/cpb.36.3453
• 作为产物：
  描述：

  diethyl (1,2,3,4,-tetrahydro-1-naphthyl)acetylmalonate 以 硫酸 、 丙酸 为溶剂， 反应 1.0h， 以77%的产率得到(1,2,3,4,-tetrahydro-1-naphthyl)acetone
  参考文献：
  名称：

  Synthesis and antiulcer activity of (isochroman-1-yl)alkylamines. II.

  摘要：

  我们准备了多种N-苯乙基-2-(异香豆烷-1-基)-1-甲基乙胺（3b）的类似物，之前发现其对阿司匹林诱导的溃疡具有抑制活性，并且没有胃抗分泌活性。我们对这些类似物进行了胃抗分泌活性和对阿司匹林诱导溃疡的抑制活性检测。研究发现，抗溃疡活性需要一个碱性胺基团。将3b的异香豆烷环替换为硫异香豆烷、香豆烷或四氢萘环，导致抗溃疡活性的显著变化。在这些类似物中，香豆烷类似物N-苯乙基-2-(香豆烷-4-基)-1-甲基乙胺（32b）显示出最强的抗溃疡活性，效果与3b相当。

  DOI：

  10.1248/cpb.36.3453

文献信息

• Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations
  作者：Qilei Zhu、Emily C. Gentry、Robert R. Knowles

  DOI：10.1002/anie.201604619

  日期：2016.8.16

  weak C−O bond. Spontaneous scission results in the formation of the stable nitroxyl radical TEMPO. as well as a reactive carbocation intermediate that can be intercepted by a wide range of nucleophiles. Notably, this process occurs under neutral conditions and at comparatively mild potentials, enabling catalytic cation generation in the presence of both acid sensitive and easily oxidized nucleophilic

  描述了一种新的催化方法，该方法通过烷氧基胺自由基阳离子的介观裂解来获得碳正离子中间体。在此过程中，激发态氧化剂与TEMPO衍生的烷氧基胺底物之间的电子转移会产生带有非常弱的C-O键的自由基阳离子。自发断裂导致形成稳定的硝基自由基TEMPO 。以及可被多种亲核试剂截获的反应性碳正离子中间体。值得注意的是，该过程在中性条件下和相对温和的电势下发生，从而在酸敏感和易氧化的亲核分子同时存在的情况下能够产生催化阳离子。
• Arylalkylamine derivatives
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0404197A2

  公开（公告）日：1990-12-27

  Disclosed is a novel arylalkylamine derivative represented by the formula (I) wherein X represents -O-, -CH₂- or -NR³- in which R³ repre­sents hydrogen or lower alkyl; Q represents an optionally substituted aryl or option­nally substituted aromatic heterocyclic group; each of R¹ and R² independently represents hydrogen or lower alkyl; each of m and n independently represent an integer of 0 or 1; and a pharmaceutically acceptable salt thereof. The Compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory.and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.

  本发明公开了一种新型芳基烷基胺衍生物，由式 (I) 表示 其中 X 代表 -O-、-CH₂- 或 -NR³-，其中 R³ 代表氢或低级烷基； Q 代表任选取代的芳基或任选取代的芳香杂环基团； R¹和R²各自独立地代表氢或低级烷基 m和n各自独立地代表0或1的整数；以及 其药学上可接受的盐。 化合物（I）及其药学上可接受的盐具有支气管扩张和抗过敏活性，可用于治疗支气管哮喘等呼吸系统疾病。
• The slippery slope of constructivism
  作者：Terry Brumley Northcut、Nina Rovinelli Heller

  DOI：10.1080/00377310209517656

  日期：2002.3

  While constructivism as both a philosophy and a clinical practice is being embraced by many individual and family practitioners, it remains controversial. This paper examines the difficulties one encounters in trying to balance the client's "relative truths" with those around them, including that of the therapist. Through the use of clinical vignettes, the authors demonstrate the difficulties inherent in dealing with ambiguities in the clinical situation, balancing the client's perspective, with that of a predominant culture or biological "fact," and considering the issue of the client's "veracity." Particular attention is paid to the difficulties involved in work with trauma survivors, whose own recollections of events may be ambiguous. Finally, the authors discuss the implications that constructivism holds for research and social action and advocacy. In sum, the authors recognize significant promise in the constructivist perspective, but caution clinicians to consider the inherent difficulties in a theory that relies on the relativity of truth.
• YAMATO, MASATOSHI;HASHIGAKI, KUNIKO;HITOMI, SUSUMU;ISHIKAWA, SHIGETAKA, CHEM. AND PHARM. BULL., 36,(1988) N 9, C. 3453-3461
  作者：YAMATO, MASATOSHI、HASHIGAKI, KUNIKO、HITOMI, SUSUMU、ISHIKAWA, SHIGETAKA

  DOI：——

  日期：——
• US5128369A
  申请人：——

  公开号：US5128369A

  公开（公告）日：1992-07-07