2-[2-(2-Hydroxyethoxy)ethyl]-6-[2-(2-hydroxyethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione | 903499-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-[2-(2-Hydroxyethoxy)ethyl]-6-[2-(2-hydroxyethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione
• 英文别名: 2-[2-(2-hydroxyethoxy)ethyl]-6-[2-(2-hydroxyethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione
• CAS: 903499-39-8
• 化学式: C₂₀H₂₄N₂O₆
• 分子量: 388.42
• InChiKey: KEUGHCBGMSAYGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[2-(2-Hydroxyethoxy)ethyl]-6-[2-(2-hydroxyethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione 在 溴 、 三氯化磷 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 以82%的产率得到2-[2-(2-bromoethoxy)ethyl]-6-[2-(2-bromoethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

  摘要：

  Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried Out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A(2) and A(4) showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.12.012
• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 、 二甘醇胺 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 以98%的产率得到2-[2-(2-Hydroxyethoxy)ethyl]-6-[2-(2-hydroxyethoxy)ethylamino]benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

  摘要：

  Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried Out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A(2) and A(4) showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.12.012

文献信息

• [EN] MIGRATION-FREE COLOURED COPOLYCONDENSATES FOR COLOURING POLYMERS<br/>[FR] PRODUITS DE COPOLYCONDENSATION COLORÉS EXEMPTS DE MIGRATION POUR LA COLORATION DE POLYMÈRES
  申请人：BASF SE

  公开号：WO2011036075A1

  公开（公告）日：2011-03-31

  The invention relates to coloured and/or fluorescent copolycondensates which are obtained by reaction of colourants substituted by at least two reactive groups which do not interfere with one another, with selected cyclic dicarboxylic acids (especially 1,4-cyclohexanedicarboxylic acid), aliphatic diols (especially ethylene glycol), cyclic diamines (especially isophoronediamine) and/or amino acids in particular amounts.

  这项发明涉及通过对至少具有不相互干扰的两个反应基团的着色剂与选定的环形二羧酸（尤其是1,4-环己二羧酸）、脂肪二醇（尤其是乙二醇）、环状二胺（尤其是异戊二胺）和/或特定量的氨基酸进行反应而获得的着色和/或荧光共聚酰胺。
• MIGRATION-FREE COLOURED COPOLYCONDENSATES FOR COLOURING POLYMERS
  申请人：BASF SE

  公开号：EP2480610B1

  公开（公告）日：2017-11-29
• Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding
  作者：Yan Liu、Yufang Xu、Xuhong Qian、Jianwen Liu、Liyun Shen、Junhui Li、Yuanxing Zhang

  DOI：10.1016/j.bmc.2005.12.012

  日期：2006.5

  Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried Out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A(2) and A(4) showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells. (c) 2005 Elsevier Ltd. All rights reserved.