1-propylcyclopentylamine | 100877-36-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-propylcyclopentylamine
• 英文别名: 1-propyl-cyclopentylamine；1-Propyl-cyclopentylamin；1-propylcyclopentanamine；1-Propylcyclopentan-1-amine
• CAS: 100877-36-9
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: NGCNLWXCPKBKNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氯丁腈 、 (butane-1,4-diyl)dimagnesium dibromide 在 titanium(IV)isopropoxide 、 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 24.5h， 以19%的产率得到1-propylcyclopentylamine
  参考文献：
  名称：

  在 Ti(OiPr)4 存在下，来自腈和四亚甲基二溴化镁的 1-取代环戊胺

  摘要：

  通过在Ti(OiPr) 4 存在下将四亚甲基二溴化镁分别添加到脂肪族、芳香族和杂芳香族腈中，已经根据一锅法制备了各种1-取代的环戊胺（25个实施例，10-89%产率）。

  DOI：

  10.1002/ejoc.200900817

文献信息

• Hydroxyethylamine derivatives for the treatment of alzheimer's disease
  申请人：Demont H Emmanuel

  公开号：US20060025459A1

  公开（公告）日：2006-02-02

  The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

  本发明涉及具有Asp2（β-秘鲁酶、BACE1或Memapsin）抑制活性的新型羟乙基胺化合物，其制备方法，包含它们的组合物以及它们在治疗由高β-淀粉样蛋白水平或β-淀粉样蛋白沉积物所特征的疾病，特别是阿尔茨海默病中的应用。
• Process for disproportionating silanes
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0206621A1

  公开（公告）日：1986-12-30

  A process for disproportionating silanes, which comprises contacting a silane having at least one Si-H bond represented by the general formula wherein R represents an alkyl or aryl group, X represents a halogen atom or an alkoxy group, ℓis 0, 1 or 2, and m is 1, 2 or 3 and ℓ+m is 1, 2 or 3, and when fis 2, R's may be identical or different, and when ℓ+m is 1 or 2, X's may be identical or different, with a reaction product of a strong acid-type cation exchange resin with an amine.

  一种歧化硅烷的工艺，其包括与具有至少一个 Si-H 键的硅烷接触，该硅烷由通式表示 其中 R 代表烷基或芳基，X 代表卤素原子或烷氧基，ℓ 为 0、1 或 2，m 为 1、2 或 3，ℓ+m 为 1、2 或 3，当 f 为 2 时，R 可以相同或不同，当 ℓ+m 为 1 或 2 时，X 可以相同或不同。
• RUST-PREVENTIVE OIL COMPOSITION
  申请人：Nippon Mitsubishi Oil Corporation

  公开号：EP1394289A1

  公开（公告）日：2004-03-03

  The rust preventive oil composition according to the present invention contains at least one kind of sulfonate of 1 to 10% by mass selected from a group consisting of an alkaline metal sulfonate, an alkaline earth-metal sulfonate (with the exception of barium sulfonate) and an amine sulfonate based on the total weight of the composition in at least one kind of base oil selected from a group consisting of a mineral oil and a synthetic oil, and the contents of barium, zinc, chlorine and lead are each 1000ppm by mass or less based on the total weight by element conversion of the composition, and the content of a compound having a group represented by the following general formula (1): [wherein R1 represents an alkyl group having 1 to 24 carbon atoms , R2 represents an alkylene group having 2 to 4 carbon atoms, m represents an integer of 1 to 5 and n represents an integer of 1 to 6] is 1000ppm by mass or less based on the total weight of the composition.

  根据本发明的防锈油组合物，在至少一种选自矿物油和合成油的基础油中，含有 至少一种质量分数为 1-10%的磺酸盐，该磺酸盐选自碱金属磺酸盐、碱土金属磺酸盐 （磺酸钡除外）和磺酸胺，以组合物总重量为基准、钡、锌、氯和铅的含量均不超过 1000ppm（以按元素换算的组合物总重量为基准），以及具有下 列通式(1)所代表基团的化合物的含量： [其中 R1 代表具有 1 至 24 个碳原子的烷基，R2 代表具有 2 至 4 个碳原子的亚烷基，m 代表 1 至 5 的整数，n 代表 1 至 6 的整数。］ 以组合物总重量为基准，质量分数不超过 1000ppm。
• LUBRICATING OIL COMPOSITION FOR INDUSTRIAL MACHINERY AND EQUIPMENT
  申请人：Nippon Oil Corporation

  公开号：EP1734103A1

  公开（公告）日：2006-12-20

  A lubricative composition for industrial machinery and equipment which comprises a base oil selected from among mineral oils, fats and oils, synthetic oils and mixture of two or more of them, and at least one additive selected from among the following components (A) to (D): component (A): (A-1) a phosphorus-containing carboxylic acid and/or (A-2) a thiophosphoric ester, component (B): a dispersant viscosity index improver, component (C): (C-1) a specific amidocarboxylic acid compound and/or (C-2) a specific carboxylic acid compound, and component (D): an ester oiliness improver. The composition is favorable as a lubricating oil composition and useful as a gear oil composition, a lubricating oil composition for paper machines or a lubricating oil composition for slide guides, a hydraulic oil, or the like.

  一种用于工业机械和设备的润滑油组合物，包括选自矿物油、油脂、合成油和两种或两种以上矿物油混合物的基础油，以及至少一种选自以下组分（A）至（D）的添加剂：组分（A）：(A-1) 含磷羧酸和/或 (A-2) 硫代磷酸酯，成分 (B)：分散剂粘度指数改进剂，成分 (C)：(C-1) 特定酰胺羧酸化合物和/或 (C-2) 特定羧酸化合物，以及成分 (D)：酯类油性改进剂。该组合物作为润滑油组合物是有利的，可用作齿轮油组合物、造纸机润滑油组合物或滑动导轨润滑油组合物、液压油等。
• REFRIGERATOR OIL, COMPRESSOR OIL COMPOSITION, HYDRAULIC FLUID COMPOSITION, METALWORKING FLUID COMPOSITION, HEAT TREATMENT OIL COMPOSITION, LUBRICANT COMPOSITION FOR MACHINE TOOL AND LUBRICANT COMPOSITION
  申请人：Nippon Oil Corporation

  公开号：EP2039746A1

  公开（公告）日：2009-03-25

  The present invention provides a refrigerating machine oil, a compressor oil composition, a hydraulic oil composition, a metalworking oil composition, a heat treating oil composition, a lubricating oil composition for machine tools and a lubricating oil composition which comprise a lubricating oil base oil having %CA of not more than 2, %CP/%CN of not less than 6 and an iodine value of not more than 2.5.

  本发明提供了一种冷冻机油、一种压缩机油组合物、一种液压油组合物、一种金属加工油组合物、一种热处理油组合物、一种机床用润滑油组合物和一种润滑油组合物，它们由润滑油基础油组成，基础油的%CA 不大于 2，%CP/%CN 不小于 6，碘值不大于 2.5。