5-amino-1-pentanol hydrochloride | 67098-30-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-amino-1-pentanol hydrochloride
• 英文别名: 5-amino-pentan-1-ol hydrochloride；5-Aminopentan-1-ol--hydrogen chloride (1/1)；5-aminopentan-1-ol;hydrochloride
• CAS: 67098-30-0
• 化学式: C₅H₁₃NO*ClH
• 分子量: 139.625
• InChiKey: KQOBHWVHWOWXAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.53
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-amino-1-pentanol hydrochloride 、 异氰酸十一酯 以 乙腈 为溶剂， 反应 12.0h， 以77%的产率得到5-undecylcarbamoyloxypentylammonium chloride
  参考文献：
  名称：

  Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12

  摘要：

  Transkarbam 12 (5-(dodecyloxycarbonyl)pentylammonium-5-(dodecyloxycarbonyl)pentylcarbamate, T12) is a highly effective skin permeation enhancer. In this study, ester groups in the molecule of T12 were replaced by carbonate and carbamate ones, respectively. The in vitro permeation-enhancing activities were evaluated using porcine skin and compared with those of T12 and previously prepared series of amide, ketone, and alkyl analogs. According to the activities and behavior of the compounds in donor samples, ester group is essential for the activity of T12; its replacement not only decreases the enhancing potency, but is likely to change the mechanism of action.

  DOI：

  10.1016/j.bmc.2006.08.014
• 作为产物：
  描述：

  tetrahydro-2H-2-pyranol 在 ammonium acetate 、 氨 、 sodium cyanoborohydride 、 锌 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 18.0h， 生成 5-amino-1-pentanol hydrochloride 、 bis(5-hydroxypentyl)amine hydrochloride
  参考文献：
  名称：

  胺的无保护基团合成：通过还原胺化由醛类合成伯胺

  摘要：

  提出了一种新的无保护基合成伯胺的方法。通过优化金属氢化物/氨介导的醛和半缩醛的还原胺化反应，可以选择性地制备伯胺，而不会或很少会形成通常的仲胺和叔胺副产物。该方法是在一系列功能化的醛底物上进行的，包括从Vasella反应中原位形成的醛。这些还原性胺化条件提供了有价值的合成工具，用于以较少的步骤，良好的收率并且不使用保护基团来选择性生产伯胺。

  DOI：

  10.1021/jo100004c

文献信息

• [EN] A PROCESS FOR PREPARATION OF AMIDES AND ESTHERS OF 2-((2-HYDROXYPANOYL)OXY)PROPANOIC ACID<br/>[FR] PROCÉDÉ DE PRÉPARATION D'AMIDES ET D'ESTHERS DE L'ACIDE 2-((2-HYDROXYPANOYL)OXY)PROPANOÏQUE
  申请人：UNIV PARDUBICE

  公开号：WO2020125823A1

  公开（公告）日：2020-06-25

  The present invention describes method of preparation of esters or amides of lactyl lactates of general formula (I), where Z denotes to group of R-O or RR-N and R represent alkyl, aryl or H from lactide and the lactide is in contact with a hydrocarbyl alcohol and a hydrolyzable halide in a non-chlorinated organic solvent, or an amine initiated by a hydrolysable halide or hydrogen halide solution or an ammonium hydrohalide, wherein the hydrocarbyl alcohol or amine is either aliphatic or aromatic and containing 1 to 1000 carbon atoms, preferably 1 up to 150 carbon atoms, and optionally one or more, preferably 1 to 5, -CH2- groups may be replaced by -O-groups.

  本发明描述了一种制备通式（I）的乳酰乳酸酯或酰胺的方法，其中Z代表R-O或RR-N基团，R代表来自乳酸内酯的烷基、芳基或氢，而且该乳酸内酯与烃基醇和可水解卤化物在非氯有机溶剂中接触，或者在氨基引发的可水解卤化物或氢卤酸溶液或铵盐氢卤酸中接触，其中烃基醇或胺可以是脂肪族或芳香族，含有1至1000个碳原子，优选含有1至150个碳原子，并且可选地，一个或多个，优选1至5个，-CH2-基团可以被-O-基团取代。
• Copper-Catalyzed Oxidative Amidation of Aldehydes with Amine Salts: Synthesis of Primary, Secondary, and Tertiary Amides
  作者：Subhash Chandra Ghosh、Joyce S. Y. Ngiam、Abdul M. Seayad、Dang Thanh Tuan、Christina L. L. Chai、Anqi Chen

  DOI：10.1021/jo301252c

  日期：2012.9.21

  aldehydes with economic ammonium chloride or amine hydrochloride salts has been developed for the synthesis of a wide variety of amides by using inexpensive copper sulfate or copper(I) oxide as a catalyst and aqueous tert-butyl hydroperoxide as an oxidant. This amidation reaction is operationally straightforward and provides primary, secondary, and tertiary amides in good to excellent yields for most

  用于与经济氯化铵醛的酰胺化的实用方法或胺盐酸盐已经通过使用廉价的硫酸铜或铜（I）氧化物作为催化剂和水性开发了各种各样酰胺的合成叔丁基过氧化氢作为氧化剂。该酰胺化反应在操作上是直接的，并且在大多数情况下在温和的条件下利用廉价且容易获得的试剂以良好的产率和优异的产率提供伯，仲和叔酰胺。由游离胺原位形成胺盐扩大了反应的底物范围。还从其相应的手性胺合成手性酰胺，而没有可检测的外消旋作用。该酰胺形成反应的实用性已在抗心律不齐药物N-乙酰普鲁卡因胺的有效合成中得到证明。
• Ink-jet recording method using chemically-modified pigment coatings
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：EP1502760A1

  公开（公告）日：2005-02-02

  Ceramic pigment-based, chemically-modified porous coatings can be used for enhancing image permanence of ink-jet image printing. Specifically, a porous coated media sheet, comprising a media substrate, having a porous coating coated thereon comprising a ligand-modified ceramic pigment (10) including a fixer ligand (46) and/or a stabilizer ligand (48), each covalently attached to the ceramic pigment (12) is disclosed. Additionally, a method and system for preparing permanent ink-jet images is also provided.

  基于陶瓷颜料的化学改性多孔涂层可用于提高喷墨图像打印的图像持久性。具体来说，本发明公开了一种多孔涂层介质片材，包括介质基材，其上涂有多孔涂层，该涂层包括配体修饰的陶瓷颜料 (10)，其中包括固定配体 (46) 和/或稳定配体 (48)，每个配体都共价连接到陶瓷颜料 (12)。此外，还提供了一种制备永久性喷墨图像的方法和系统。
• Modified isocyanates
  申请人：——

  公开号：US20030050424A1

  公开（公告）日：2003-03-13

  The invention concerns modified isocyanates of formula (I) wherein: Iso is the radical of a (poly)isocyanate (after an isocyanate function has been transformed); X represents an atom or a group of atoms capable of reacting with the isocyanate function.

  本发明涉及式 (I) 的改性异氰酸酯，其中Iso 是（多）异氰酸酯的基团（在异氰酸酯官能团转化后）；X 代表能与异氰酸酯官能团反应的原子或原子团。
• Chemically-modified coatings for enhanced performance of ink-jet images
  申请人：——

  公开号：US20040022946A1

  公开（公告）日：2004-02-05

  Ceramic pigment-based, chemically-modified porous coatings can be used for enhancing image permanence of ink-jet image printing. Specifically, a porous coated media sheet, comprising a media substrate, having a porous coating coated thereon comprising a modified ceramic pigment including a fixer group and a stabilizer group, each covalently attached to the ceramic pigment is disclosed. Additionally, a method and system for preparing permanent ink-jet images is also provided.

  基于陶瓷颜料的化学改性多孔涂层可用于提高喷墨图像印刷的图像持久性。具体来说，本发明公开了一种多孔涂层介质片材，包括介质基材，其上涂有多孔涂层，该涂层由改性陶瓷颜料组成，包括固定基团和稳定基团，每个基团都共价连接到陶瓷颜料上。此外，还提供了一种制备永久性喷墨图像的方法和系统。