6-aminohexan-1-ol hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-aminohexan-1-ol hydrochloride
• 英文别名: 6-Hydroxyhexan-1-aminium chloride；6-hydroxyhexylazanium;chloride
• 化学式: C₆H₁₅NO*ClH
• 分子量: 153.652
• InChiKey: OTZWMVVGGCDNMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.92
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5'-O-(p,p'-dimethoxytrityl)thymidine 3'-(2-cyanoethyl) H-phosphonate 、 6-aminohexan-1-ol hydrochloride 在 碘 作用下， 以 吡啶 为溶剂， 反应 0.5h， 生成 6-aminohexyl [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 2-cyanoethyl phosphate
  参考文献：
  名称：

  核苷H-膦酸酯二酯与双功能试剂反应的研究。第4部分。核苷H-膦酸酯二酯与氨基醇质子化控制的氨基醇的氧化偶联过程中的化学选择性

  摘要：

  碘促进的H-膦酸酯二酯与氨基醇的氧化偶联过程可以通过氨基醇的胺官能化来控制。基于这种现象，开发了一种快速有效的合成氨基烷基磷酸三酯或羟烷基氨基磷酸酯的方法。

  DOI：

  10.1016/0040-4039(95)00238-8

文献信息

• Bifunctional ligands based on the DOTA-monoamide cage
  作者：Alessandro Barge、Lorenzo Tei、Dharita Upadhyaya、Franco Fedeli、Lorena Beltrami、Rachele Stefanìa、Silvio Aime、Giancarlo Cravotto

  DOI：10.1039/b715844k

  日期：——

  Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

  本文介绍了获得带有氨基、羟基、醛基和马来酰亚胺基团的 DOTA-单酰胺配体的有效途径。这些官能团可随意与配位笼保持一定间距，很容易与合适的靶向基团发生反应。以这种方式获得的生物共轭物可用于诊断成像和治疗应用。
• Post-cross-linked polymeric gels
  申请人：Gregor, Harry P.

  公开号：EP0240586A1

  公开（公告）日：1987-10-14

  Cross-linked polymeric gels or films are prepared by dissolving in a suitable solvent a linear polymer or polymers at least one of which is predominantly (at least 80%) made from monomers containing pendant amidocarbonyl or oxycarbonyl groups. For the cross-linking reaction are present either hydroxyl groups, present as either pendant groups from the polymer, or as low molecular weight polyols; or amino groups, present as either pendant groups from the polymer, or as low molecular weight diamines or polyamines. Either no catalyst is present or a strongly acidic catalyst (which may also be a pendant group on a polymer) is used. The solvent is removed by coagulation and/or drying and the dry material is heat-cured, thus cross-linking and insolubilizing the polymer or polymers.

  交联聚合物凝胶或薄膜的制备方法是将一种或多种线性聚合物溶解在适当的溶 剂中，其中至少有一种聚合物主要（至少 80%）是由含有氨基羰基或氧羰基的单体制 成的。在进行交联反应时，可使用羟基（以聚合物的悬垂基团或低分子量多元醇的形式存在）或氨基（以聚合物的悬垂基团或低分子量二胺或多胺的形式存在）。或者不使用催化剂，或者使用强酸性催化剂（也可以是聚合物上的悬垂基团）。通过凝结和/或干燥去除溶剂，然后对干燥材料进行热固化，从而使聚合物交联和不溶解。
• Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12
  作者：Tomáš Holas、Kateřina Vávrová、Martin Šíma、Jana Klimentová、Alexandr Hrabálek

  DOI：10.1016/j.bmc.2006.08.014

  日期：2006.12

  Transkarbam 12 (5-(dodecyloxycarbonyl)pentylammonium-5-(dodecyloxycarbonyl)pentylcarbamate, T12) is a highly effective skin permeation enhancer. In this study, ester groups in the molecule of T12 were replaced by carbonate and carbamate ones, respectively. The in vitro permeation-enhancing activities were evaluated using porcine skin and compared with those of T12 and previously prepared series of amide, ketone, and alkyl analogs. According to the activities and behavior of the compounds in donor samples, ester group is essential for the activity of T12; its replacement not only decreases the enhancing potency, but is likely to change the mechanism of action.
• Korshunov,M.A. et al., Journal of Organic Chemistry USSR (English Translation), 1969, vol. 5, # 2, p. 244 - 251
  作者：Korshunov,M.A. et al.

  DOI：——

  日期：——
• Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response
  作者：Ming-Hsiu Yang、Jamie L. Russell、Yuto Mifune、Ying Wang、Hexin Shi、Eva Marie Y. Moresco、Daniel J. Siegwart、Bruce Beutler、Dale L. Boger

  DOI：10.1021/acs.jmedchem.2c00419

  日期：2022.7.14