bromoacetylamido-Rh110-azido | 1027627-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: bromoacetylamido-Rh110-azido
• 英文别名: N-(6'-azido-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl)-2-bromoacetamide
• CAS: 1027627-69-5
• 化学式: C₂₂H₁₃BrN₄O₄
• 分子量: 477.274
• InChiKey: PSHRHVAWSYCWND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  溴乙酰溴 、 3-amino-6-azidoxanthene-9'-spiro-1'-isobenzofuran-3'(1'H)-one 在 potassium carbonate 作用下， 以 氯仿 为溶剂， 以94%的产率得到bromoacetylamido-Rh110-azido
  参考文献：
  名称：

  EP2103616

  摘要：

  公开号：

文献信息

• FLUORESCENT MOLECULE
  申请人：Riken

  公开号：EP2103616A1

  公开（公告）日：2009-09-23

  It is an object of the present invention to provide an on-off type fluorescent compound used in gene analyses, which is highly stable and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention provides a compound represented by the following formula (1) or (2): wherein R1 represents an alkyl group containing 1 to 6 carbon atoms, an amino group, an amide group optionally having a protecting group or a substituent, a halogen atom, or a hydrogen atom; R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom; R3 represents an alkyl group containing 1 to 6 carbon atoms, an aryl group, or a hydrogen atom; R4 represents a group containing an oxygen atom, or a hydrogen atom, wherein R3 may bind to R4 to form a ring.

  本发明的目的是提供一种用于基因分析的开关型荧光化合物，它具有高稳定性和高灵敏度，能放大微量基因信号并对其进行观察。本发明提供了由下式（1）或（2）代表的化合物： 其中 R1 代表含有 1 至 6 个碳原子的烷基、氨基、可选择具有保护基团或取代基的酰胺基、卤素原子或氢原子；R2 独立地代表含有 1 至 6 个碳原子的烷基、卤素原子或氢原子；R3 代表含有 1 至 6 个碳原子的烷基、芳基或氢原子；R4 代表含有氧原子或氢原子的基团，其中 R3 可与 R4 结合形成环。
• FLUORESCENCE-PRODUCING MOLECULE
  申请人：Abe Hiroshi

  公开号：US20100190159A1

  公开（公告）日：2010-07-29

  It is an object of the present invention to provide an on-off type fluorescent compound used in gene analyses, which is highly stable and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention provides a compound represented by the following formula (1) or (2): wherein R 1 represents an alkyl group containing 1 to 6 carbon atoms, an amino group, an amide group optionally having a protecting group or a substituent, a halogen atom, or a hydrogen atom; R 2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom; R 3 represents an alkyl group containing 1 to 6 carbon atoms, an aryl group, or a hydrogen atom; R 4 represents a group containing an oxygen atom, or a hydrogen atom, wherein R 3 may bind to R 4 to form a ring.
• US8426127B2
  申请人：——

  公开号：US8426127B2

  公开（公告）日：2013-04-23
• EP2103616
  申请人：——

  公开号：——

  公开（公告）日：——