Isoquinoline, 4-(4-morpholinyl)- | 501954-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Isoquinoline, 4-(4-morpholinyl)-
• 英文别名: 4-isoquinolin-4-ylmorpholine
• CAS: 501954-43-4
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: BYZLEDOQYUJIRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 4-溴异喹啉 在 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 potassium fluoride on basic alumina 作用下， 反应 6.0h， 以86%的产率得到Isoquinoline, 4-(4-morpholinyl)-
  参考文献：
  名称：

  Palladium-catalysed amination of halopyridines on a KF-alumina surface

  摘要：

  Palladium-catalysed C-N hetero cross-coupling reactions between bromopyridines and amines (both primary and secondary) can be efficiently performed on a KF-alumina (basic) surface, thus negating the use of strong bases such as sodium tert-butoxide. The reaction conditions are optimised with reference to catalytic systems, solvents and the surface. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01852-x

文献信息

• [EN] 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS<br/>[FR] 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES UTILISEES POUR TRAITER DES TROUBLES DONT LA MEDIATION EST ASSUREE PAR DES KINASES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006130673A1

  公开（公告）日：2006-12-07

  [EN] The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.
  [FR] L'invention concerne de nouveaux composés 3-benzoimidazolyl-pyrazolopyridine de formule (I), et des formes pharmaceutiquement acceptables de ces composés. La présente invention concerne également la synthèse et l'utilisation desdits composés en tant qu'inhibiteurs des protéines kinases sérine-thréonine et des protéines kinases tyrosine et des interactions correspondantes.
• Palladium-catalysed amination of halopyridines on a KF-alumina surface
  作者：Basudeb Basu、Satadru Jha、Niranjan K. Mridha、Md.Mosharef H. Bhuiyan

  DOI：10.1016/s0040-4039(02)01852-x

  日期：2002.10

  Palladium-catalysed C-N hetero cross-coupling reactions between bromopyridines and amines (both primary and secondary) can be efficiently performed on a KF-alumina (basic) surface, thus negating the use of strong bases such as sodium tert-butoxide. The reaction conditions are optimised with reference to catalytic systems, solvents and the surface. (C) 2002 Elsevier Science Ltd. All rights reserved.