O^5'-(O^5'-phosphono-[3']thymidylyl)-[3']thymidylic acid | 2642-41-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （3'->5'）-二核苷酸和类似物
• 英文名称: O^5'-(O^5'-phosphono-[3']thymidylyl)-[3']thymidylic acid
• 英文别名: O^5'-(O^5'-Phosphono-[3']thymidylyl)-[3']thymidylsaeure；P-dThd-P-dThd-P；[(2R,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2-(phosphonooxymethyl)oxolan-3-yl] [(2R,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate
• CAS: 2642-41-3
• 化学式: C₂₀H₂₉N₄O₁₈P₃
• 分子量: 706.388
• InChiKey: UGGKQFBASMPLHR-KPRKPIBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  307
• 氢给体数：
  7
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  thymidine-3'-bis(p-nitrophenylethyl)phosphate 在 N-甲基咪唑 、 triisopropylbenzenesulfonylchloride 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 吡啶 为溶剂， 反应 24.0h， 生成 O^5'-(O^5'-phosphono-[3']thymidylyl)-[3']thymidylic acid
  参考文献：
  名称：

  双（对硝基苯基乙基）磷酸一氯代酯，一种新型多功能磷酸化剂

  摘要：

  已经制备了一种新的磷酸化剂，双-（对-硝基苯基乙基）磷酸一氯代磷酸酯，并用于核苷的3'-和/或5'-磷酸化。所得的双-（对硝基苯基乙基）磷酸三酯是寡核苷酸合成中的通用合成子，最终以优异的产率产生了3'-和/或5'-末端的寡核苷酸。

  DOI：

  10.1016/s0040-4039(00)85715-9

文献信息

• Diabetes in Elderly Adults
  作者：G. S. Meneilly、D. Tessier

  DOI：10.1093/gerona/56.1.m5

  日期：2001.1.1

  Diabetes is common in the elderly population. By the age of 75, approximately 20% of the population are afflicted with this illness. Diabetes in elderly adults is metabolically distinct from diabetes in)younger patient populations, and the approach to therapy needs to be different in this age group. Diabetes is associated with substantial morbidity from macro- and microvascular complications. Several lines of evidence suggest that optimal glycemic control and risk factor modification can substantially reduce the risk of complications in elderly patients. In the past, treatment options were limited. However, recent studies have delineated several new and exciting therapeutic opportunities for elderly patients with diabetes.
• Bis-(p-nitrophenylethyl)phosphoromonochloridate, a new versatile phosphorylating agent
  作者：Frank Himmelsbach、Wolfgang Pfleiderer

  DOI：10.1016/s0040-4039(00)85715-9

  日期：1982.1

  agent, bis-(p-nitrophenylethyl)phoshoromonochloridate, has been prepared and is used for 3′- and/or 5′-phosphorylations of nucleosides. The resulting bis-(p-nitrophenylethyl)phosphotriesters are versatile synthons in oligonucleotide syntheses leading finally to 3′- and/or 5′-terminated oligonucleotides in excellent yields.

  已经制备了一种新的磷酸化剂，双-（对-硝基苯基乙基）磷酸一氯代磷酸酯，并用于核苷的3'-和/或5'-磷酸化。所得的双-（对硝基苯基乙基）磷酸三酯是寡核苷酸合成中的通用合成子，最终以优异的产率产生了3'-和/或5'-末端的寡核苷酸。