4-Amino-1-[5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 4-Amino-1-[5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
• 化学式: C₁₀H₁₅N₃O₃
• 分子量: 225.24
• InChiKey: JNQYNXFGVRUFNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TAU-TARGETING OLIGONUCLEOTIDE GAPMERS
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20220195437A1

  公开（公告）日：2022-06-23

  Antisense oligonucleotides are provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription. Inhibition of Tau mRNA transcription may result in decrease of amounts of Tau protein in a subject, allowing treatment of diseases and disorders related to expression of Tau, including Alzheimer's disease and primary tauopathies.

  提供了反义寡核苷酸。这些反义寡核苷酸在制备gapmers以抑制Tau mRNA转录方面非常有用。抑制Tau mRNA转录可能导致受试者Tau蛋白质量的降低，从而治疗与Tau表达有关的疾病和疾病，包括阿尔茨海默病和原发性Tau病。
• MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
  申请人：Translate Bio MA, Inc.

  公开号：EP2756080B1

  公开（公告）日：2019-02-20
• [EN] EVOLUTION BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION<br/>[FR] ÉVOLUTION DE POLYMÈRES SYNTHÉTIQUES DÉFINIS PAR SÉQUENCE BIOACTIVE À L'AIDE D'UNE POLYMÉRISATION À MATRICE D'ADN
  申请人：HARVARD COLLEGE

  公开号：WO2019010441A1

  公开（公告）日：2019-01-10

  The present invention provides methods and compositions for performing ordered multi- step syntheses involving modified nucleic acids by nucleic acid-mediated chemistry. This approach is useful for generating sequence-defined highly functionalized nucleic acid polymers. The invention also provides modified nucleic acid polymers that bind to proteins of interest (e.g., PCSK9 and IL-6), which are implicated in human disease.
• [EN] POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS<br/>[FR] GAPMÈRES DE POLY-MORPHOLINO OLIGONUCLÉOTIDES
  申请人：[en]EISAI R&D MANAGEMENT CO., LTD.

  公开号：WO2022125987A1

  公开（公告）日：2022-06-16

  Gapmers or pharmaceutically acceptable salt of the gapmers and methods of making the gapmers are provided. The gapmers include a gap region that contains deoxyribonucleosides linked to each other by phosphorothioate bonds, a 5' wing region positioned at the 5' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds, and a 3' wing region positioned at the 3' end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds. Antisense oligonucleotides are also provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription.
• [EN] TAU-TARGETING OLIGONUCLEOTIDE GAPMERS<br/>[FR] GAPMÈRES OLIGONUCLÉOTIDIQUES CIBLANT TAU
  申请人：[en]EISAI R&D MANAGEMENT CO., LTD.

  公开号：WO2022125984A1

  公开（公告）日：2022-06-16

  Antisense oligonucleotides are provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription. Inhibition of Tau mRNA transcription may result in decrease of amounts of Tau protein in a subject, allowing treatment of diseases and disorders related to expression of Tau, including Alzheimer's disease and primary tauopathies.