1-[4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C₁₀H₁₅N₃O₄
• 分子量: 241.24
• InChiKey: ADVCGXWUUOVPPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

ADMET

代谢

3p-氨基-3p-脱氧胸腺嘧啶已知的人类代谢物包括(2S,3S,4S,5R)-4-[[3-氨基-5-(5-甲基-2,4-二氧嘧啶-1-基)氧杂戊烷-2-基]甲氧基]-3,5,6-三羟基氧杂环己烷-2-羧酸。

3p-Amino-3p-deoxythimidine has known human metabolites that include (2S,3S,4S,5R)-4-[[3-Amino-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-3,5,6-trihydroxyoxane-2-carboxylic acid.

来源:NORMAN Suspect List Exchange

文献信息

• Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same
  申请人：Laboratory Skin Care, Inc.

  公开号：US10758478B2

  公开（公告）日：2020-09-01

  Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.

  本发明提供了均匀、坚硬、球形的纳米多孔磷酸钙颗粒，这些颗粒限定了内部空间和内部空间中的活性剂含量。此外，还提供了包括活性剂负载颗粒的局部给药组合物，以及制造颗粒和局部组合物的方法。这些颗粒及其组合物可用于各种不同的应用，包括活性剂递送应用。
• VITAMIN B6 DERIVATIVES OF NUCLEOTIDES, ACYCLONUCLEOTIDES AND ACYCLONUCLEOSIDE PHOSPHONATES
  申请人：MBC Pharma, Inc.

  公开号：EP2739154B1

  公开（公告）日：2018-06-27
• [EN] ACTIVE AGENT LOADED UNIFORM, RIGID, SPHERICAL, NANOPOROUS CALCIUM PHOSPHATE PARTICLES AND METHODS OF MAKING AND USING THE SAME<br/>[FR] PARTICULES DE PHOSPHATE DE CALCIUM UNIFORMES, RIGIDES, SPHÉRIQUES, NANOPOREUSES CHARGÉES DE PRINCIPE ACTIF ET LEURS MÉTHODES DE FABRICATION ET D'UTILISATION
  申请人：LAB SKIN CARE INC

  公开号：WO2010039560A2

  公开（公告）日：2010-04-08

  Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.