2-amino-9-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-1H-purin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-9-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-1H-purin-6-one
• 化学式: C₁₀H₁₁N₅O₃
• 分子量: 249.23
• InChiKey: FZYYPNOHKXTKLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• RIBOSWITCHES
  申请人：The University Of Manchester

  公开号：EP2707487B1

  公开（公告）日：2017-10-04
• [EN] RIBOSWITCHES<br/>[FR] RIBORÉGULATEURS
  申请人：UNIV MANCHESTER

  公开号：WO2012153142A2

  公开（公告）日：2012-11-15

  The present invention relates to a system comprising a genetic construct a riboswitch operably linked to a regulatory sequence, and a second genetic construct a coding sequence whose expression is capable of being regulated by a gene product of the first construct. Also provided is a genetic construct comprising one or more riboswitches for regulation of gene expression, wherein preferably a spacer sequence is provided downstream of the riboswitch to enhance expression of a coding sequence which is operably linked to a riboswitch. Ligands, kits, methods, host cells and expression systems are also provided.