(E)-4-hydroxy-4-(naphthalen-2-yl)but-2-enyl propionate | 1210067-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-4-hydroxy-4-(naphthalen-2-yl)but-2-enyl propionate
• 英文别名: [(E)-4-hydroxy-4-naphthalen-2-ylbut-2-enyl] propanoate
• CAS: 1210067-02-9
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.328
• InChiKey: SQDPQCBDVBKVLY-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(萘-2-基)-丁-3-烯-1-醇 、 丙酸 在 lithium hydroxide monohydrate 、 palladium diacetate 、 丙酸 、 对苯醌 作用下， 反应 24.42h， 以60%的产率得到(E)-4-hydroxy-4-(naphthalen-2-yl)but-2-enyl propionate
  参考文献：
  名称：

  Palladium-Catalyzed Allylic Acyloxylation of Terminal Alkenes in the Presence of a Base

  摘要：

  The efficiency and the selectivity of the Pd-catalyzed oxidation, in carboxylic acids, of terminal alkenes are strongly improved ill the presence of a base. The methodology IS particularly Well adapted for the oxidation homoallylic alcohols, for which the resulting acyloxylated products are obtained selectively as E-isomers in fair to good yields.

  DOI：

  10.1021/jo902587u

文献信息

• Palladium-Catalyzed Allylic Acyloxylation of Terminal Alkenes in the Presence of a Base
  作者：Emilie Thiery、Chahinez Aouf、Julien Belloy、Dominique Harakat、Jean Le Bras、Jacques Muzart

  DOI：10.1021/jo902587u

  日期：2010.3.5

  The efficiency and the selectivity of the Pd-catalyzed oxidation, in carboxylic acids, of terminal alkenes are strongly improved ill the presence of a base. The methodology IS particularly Well adapted for the oxidation homoallylic alcohols, for which the resulting acyloxylated products are obtained selectively as E-isomers in fair to good yields.