8-(4-methoxyanilino)-1,3-dimethyl-7H-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(4-methoxyanilino)-1,3-dimethyl-7H-purine-2,6-dione
• 化学式: C₁₄H₁₅N₅O₃
• mdl: MFCD04156369
• 分子量: 301.3
• InChiKey: RICCWHOMSSUHEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compounds for repressing cancer cell growth
  申请人：Institute For Cancer Research

  公开号：US11203598B2

  公开（公告）日：2021-12-21

  The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth. In particular, the compounds comprise Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen or a haloalkyl group; and each R2, R3, R4, R5, R6, and R7 is, independently, hydrogen, halogen, hydroxyl, cyano, alkyl, alkenyl, alkoxy, substituted or unsubstituted aryl, heteroaryl, phosphate, phosphoramidate, amine, alkylamino, acylamino, aminoalkoxy, or alkylthio.

  本公开一般涉及通过恢复 P53 通路信号抑制癌细胞生长来治疗癌症的化合物、组合物和方法。特别是，这些化合物包括式 I： 或其药学上可接受的盐，其中R1 是氢或卤代烷基；R2、R3、R4、R5、R6 和 R7 各自独立地是氢、卤素、羟基、氰基、烷基、烯基、烷氧基、取代或未取代的芳基、杂芳基、磷酸、磷酰胺、胺、烷基氨基、酰基氨基、氨基烷氧基或烷硫基。
• Compounds For Repressing Cancer Cell Growth
  申请人：Institute For Cancer Research d/b/a The Research Institute Of Fox Chase Cancer Center

  公开号：US20190225613A1

  公开（公告）日：2019-07-25

  The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth.