1,9-Bis-methoxymethyl-3,7-dimethyl-5-oxy-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 1,9-Bis-methoxymethyl-3,7-dimethyl-5-oxy-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone
• 英文别名: 1,9-Bis(methoxymethyl)-3,7-dimethyl-5-oxidopyrimido[5,4-g]pteridin-5-ium-2,4,6,8-tetrone
• 化学式: C₁₄H₁₆N₆O₇
• 分子量: 380.317
• InChiKey: QSCPXNCARHFRGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,9-Bis-methoxymethyl-3,7-dimethyl-5-oxy-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone 在 水 作用下， 反应 1.0h， 以100%的产率得到1,9-Bis-methoxymethyl-3,7-dimethyl-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone
  参考文献：
  名称：

  Facile generation of hydroxyl radical by photolyis of pyrimido[5,4-g]pteridinetetrone N-oxides in aqueous solution. A new efficient DNA-photocleaving agent

  摘要：

  Photolyis of pyrimido[5,4-g]pteridinetetrone N-oxide 2 in water with UV–VIS light (>355 nm) provides a convenient and efficient method for the clean generation of hydroxyl radicals, which are useful as DNA-cleaving agents.

  DOI：

  10.1039/c39930000750
• 作为产物：
  描述：

  6-amino-1-methoxymethyl-3-methyl-5-nitrosouracil 在 lead(IV) acetate 作用下， 以 溶剂黄146 为溶剂， 以50%的产率得到1,9-Bis-methoxymethyl-3,7-dimethyl-5-oxy-1H,9H-pyrimido[5,4-g]pteridine-2,4,6,8-tetraone
  参考文献：
  名称：

  Facile generation of hydroxyl radical by photolyis of pyrimido[5,4-g]pteridinetetrone N-oxides in aqueous solution. A new efficient DNA-photocleaving agent

  摘要：

  Photolyis of pyrimido[5,4-g]pteridinetetrone N-oxide 2 in water with UV–VIS light (>355 nm) provides a convenient and efficient method for the clean generation of hydroxyl radicals, which are useful as DNA-cleaving agents.

  DOI：

  10.1039/c39930000750

文献信息

• Facile generation of hydroxyl radical by photolyis of pyrimido[5,4-g]pteridinetetrone N-oxides in aqueous solution. A new efficient DNA-photocleaving agent
  作者：Magoichi Sako、Katsuyuki Nagai、Yoshifumi Maki

  DOI：10.1039/c39930000750

  日期：——

  Photolyis of pyrimido[5,4-g]pteridinetetrone N-oxide 2 in water with UV–VIS light (>355 nm) provides a convenient and efficient method for the clean generation of hydroxyl radicals, which are useful as DNA-cleaving agents.