Ethyl 7-fluoro-3-hydroxy-6-morpholino-quinoxaline-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Ethyl 7-fluoro-3-hydroxy-6-morpholino-quinoxaline-2-carboxylate
• 英文别名: ethyl 7-fluoro-6-morpholin-4-yl-3-oxo-4H-quinoxaline-2-carboxylate
• 化学式: C₁₅H₁₆FN₃O₄
• 分子量: 321.308
• InChiKey: FBTVVEKZLLDXHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氟-5-(吗啉代)-2-硝基苯胺 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 Ethyl 7-fluoro-3-hydroxy-6-morpholino-quinoxaline-2-carboxylate
  参考文献：
  名称：

  Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity

  摘要：

  A series of variously substituted quinoxalin-3-ones bearing an ethoxycarbonyl or carboxy group in the C-2 position has been prepared and their structures proved by H-1 NMR spectroscopy. The obtained compounds were investigated in vitro for antimicrobial and anticancer activities. Preliminary results showed a moderate activity against a few strains of bacteria but no significant anticancer and anti-HIV activity. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00044-5