(1R,12R)-1,12,15,15,21,21-Hexamethyl-2,5,8,11-tetraoxa-14,17,20,23-tetraaza-bicyclo[10.6.6]tetracosane-13,19-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (1R,12R)-1,12,15,15,21,21-Hexamethyl-2,5,8,11-tetraoxa-14,17,20,23-tetraaza-bicyclo[10.6.6]tetracosane-13,19-dione
• 英文别名: (1R,12R)-1,12,15,15,21,21-hexamethyl-2,5,8,11-tetraoxa-14,17,20,23-tetrazabicyclo[10.6.6]tetracosane-13,19-dione
• 化学式: C₂₂H₄₂N₄O₆
• 分子量: 458.599
• InChiKey: CHJKWTVAGDXQNA-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2,6-Trimethyl-6-[2-[2-[2-[(2,2,6-trimethyl-7-oxo-1,4-diazabicyclo[3.2.0]heptan-6-yl)oxy]ethoxy]ethoxy]ethoxy]-1,4-diazabicyclo[3.2.0]heptan-7-one 在 camphor-10-sulfonic acid 、 溴甲酚绿 、 sodium cyanoborohydride 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 72.0h， 以30%的产率得到(1R,12R)-1,12,15,15,21,21-Hexamethyl-2,5,8,11-tetraoxa-14,17,20,23-tetraaza-bicyclo[10.6.6]tetracosane-13,19-dione
  参考文献：
  名称：

  Synthesis and Complexation Properties of Poly(ethylene glycol)-Linked Mono- and Bis-dioxocyclams

  摘要：

  Both tri- and tetra(ethylene glycol) linked bis-chromium carbene complexes have been synthesized. These carbene complexes were photolyzed with N-protected imidazolines to give protected azapenams. These were transformed into polyether-linked basket dioxacyclams 4a,b and bis-dioxocyclams 5a,b. These compounds have-cavities for the complexation of both "hard" and "soft" metal ions.;The complexes of Ni, Ba, and Gd were synthesized.

  DOI：

  10.1021/jo001095q

文献信息

• Synthesis and Complexation Properties of Poly(ethylene glycol)-Linked Mono- and Bis-dioxocyclams
  作者：Kurt Puntener、Mellissa D. Hellman、Erik Kuester、Louis S. Hegedus

  DOI：10.1021/jo001095q

  日期：2000.12.1

  Both tri- and tetra(ethylene glycol) linked bis-chromium carbene complexes have been synthesized. These carbene complexes were photolyzed with N-protected imidazolines to give protected azapenams. These were transformed into polyether-linked basket dioxacyclams 4a,b and bis-dioxocyclams 5a,b. These compounds have-cavities for the complexation of both "hard" and "soft" metal ions.;The complexes of Ni, Ba, and Gd were synthesized.