3,7-Diamino-phenothiazin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3,7-Diamino-phenothiazin
• 英文别名: thionine；3H-phenothiazine-3,7-diamine
• 化学式: C₁₂H₁₁N₃S
• 分子量: 229.305
• InChiKey: XHERJWTTXZCIDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• FORMULATIONS FOR USE IN THE PREVENTION AND/OR TREATMENT OF PERIPHERAL NEUROPATHY AND ITS ASSOCIATED DISEASES
  申请人：LOH Yin Sze

  公开号：US20220387440A1

  公开（公告）日：2022-12-08

  The invention relates to formulations and methods of using formulations of topical preparation of diaminophenothiazine compounds such as 3,7-bis(dimethylamino)phenothiazin-5-ium chloride in the prevention and/or treatment of peripheral neuropathy and its associated conditions, particularly in the eye. In a preferred embodiment, a topical formulation comprising 3,7-bis(dimethylamino)phenothiazin-5-ium chloride encapsulate in poly(lactic-co-glycolic acid (PLGA) microparticles is prepared, wherein the microparticles are coated with a mucoadhesive agent such as chitosan.
• [EN] DIAMINOPHENOTHIAZINE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS DE DIAMINOPHENOTHIAZINE ET UTILISATIONS ASSOCIEES
  申请人：CHILDRENS HOSP & RES CT OAK

  公开号：WO2006089301A2

  公开（公告）日：2006-08-24

  [EN] Cell senescence is delayed by contacting a cell specifically determined to be in need of delayed cell senescence with an effective amount of a diaminophenothiazine.
  [FR] Le vieillissement cellulaire est retardé par mise en contact d'une cellule qui a précisément besoin d'un vieillissement cellulaire retardé au moyen d'une quantité efficace d'un diaminophenothiazine.
• [EN] FORMULATIONS FOR USE IN THE PREVENTION AND/OR TREATMENT OF PERIPHERAL NEUROPATHY AND ITS ASSOCIATED DISEASES.<br/>[FR] FORMULATIONS DESTINÉES À ÊTRE UTILISÉE DANS LA PRÉVENTION ET/OU LE TRAITEMENT DE NEUROPATHIE PÉRIPHÉRIQUE ET SES MALADIES ASSOCIÉES
  申请人：LOH YIN SZE

  公开号：WO2021034267A1

  公开（公告）日：2021-02-25

  The invention relates to formulations and methods of using formulations of topical preparation of diaminophenothiazine compounds such as 3,7-bis(dimethylamino)phenothiazin-5-ium chloride in the prevention and/or treatment of peripheral neuropathy and its associated conditions, particularly in the eye. In a preferred embodiment, a topical formulation comprising 3,7-bis(dimethylamino)phenothiazin-5-ium chloride encapsulate in poly(lactic-co-glycolic acid (PLGA) microparticles is prepared, wherein the microparticles are coated with a mucoadhesive agent such as chitosan.