5-oxa-6-azaspiro[3.4]oct-6-ene | 1160604-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 5-oxa-6-azaspiro[3.4]oct-6-ene
• 英文别名: 5-Oxa-6-azaspiro[3.4]oct-6-ene
• CAS: 1160604-09-0
• 化学式: C₆H₉NO
• 分子量: 111.144
• InChiKey: RVMVZMJGDVHJNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-Amino-spirohexan 在 间氯过氧苯甲酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 以54%的产率得到5-oxa-6-azaspiro[3.4]oct-6-ene
  参考文献：
  名称：

  通过氧化相应的氨基衍生物首次合成硝基取代的环丙烷和螺环戊烷

  摘要：

  据报道，通过相应的胺与二甲基二环氧乙烷的氧化反应，制得硝基取代的环丙烷和螺环戊烷的新方法。该方法已成功用于一系列硝基环丙烷的制备以及1,4-二硝基螺[2.2]戊烷的首次合成。

  DOI：

  10.1016/j.tetlet.2009.03.165

文献信息

• NOVEL METHOD FOR PRODUCING 5, 5-DISUBSTITUTED-4, 5-DIHYDROISOXAZOLE
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US20210047280A1

  公开（公告）日：2021-02-18

  The present invention addresses the problem of providing an industrially preferable, economical, and environmentally friendly method for producing the 4,5-dihydroisoxazole represented by a formula (3). The present invention enables the compound of a formula (3) to be produced by reacting the compound of a formula (2) according to the reaction represented by a reaction formula in the presence of an acid catalyst.

  本发明解决了提供一种工业上更可取、经济实惠且环保的生产4,5-二氢异噁唑的方法的问题，该4,5-二氢异噁唑由式（3）表示。本发明使得按照反应方程式中所表示的反应，在酸催化剂存在下，使得式（2）化合物发生反应从而生产式（3）化合物成为可能。
• Method for producing thiocarboxamidine salt compound
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US10844024B1

  公开（公告）日：2020-11-24

  The present disclosure provides an industrially preferable, economical, and environmentally friendly method for producing a compound [C1] of formula (5), namely, a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound. The present disclosure relates to a method wherein: a reaction expressed by reaction formula [C2] is caused so as to produce a compound of formula (4) by reacting a compound of formula (3) with a halogenation agent in the presence of a nitrile solvent, and the compound of formula (4) is subsequently reacted with an isothiouronium-forming agent, thereby producing a compound of formula (5).

  本公开提供了一种在工业上更为优选、经济、环保的制备化合物[C1]的方法，即(4,5-二氢异噁唑-3-基)硫代氨基甲酸盐化合物的方法。本公开涉及一种方法，其中：在腈溶剂存在下，通过反应式[C2]所表达的反应，将式(3)的化合物与卤化试剂反应，制备出式(4)的化合物，随后将式(4)的化合物与异硫脲形成试剂反应，从而制备出式(5)的化合物。
• NOVEL METHOD FOR PRODUCING 5,5-DISUBSTITUTED-4,5-DIHYDROISOXAZOLE
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：EP3725782A1

  公开（公告）日：2020-10-21

  The present invention addresses the problem of providing an industrially preferable, economical, and environmentally friendly method for producing the 4,5-dihydroisoxazole represented by a formula (3). The present invention enables the compound of a formula (3) to be produced by reacting the compound of a formula (2) according to the reaction represented by a reaction formula in the presence of an acid catalyst.

  本发明所要解决的问题是提供一种工业上可取的、经济的和环保的方法来生产式（3）所代表的 4,5-二氢异噁唑。 本发明通过在酸催化剂存在下，根据反应式所代表的反应，使式（2）化合物发生反应，从而制得式（3）化合物。
• METHOD FOR PRODUCING THIOCARBOXAMIDINE SALT COMPOUND
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：EP3733652A1

  公开（公告）日：2020-11-04

  The present disclosure provides an industrially preferable, economical, and environmentally friendly method for producing a compound [C1] of formula (5), namely, a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound. The present disclosure relates to a method wherein: a reaction expressed by reaction formula [C2] is caused so as to produce a compound of formula (4) by reacting a compound of formula (3) with a halogenation agent in the presence of a nitrile solvent, and the compound of formula (4) is subsequently reacted with an isothiouronium-forming agent, thereby producing a compound of formula (5).

  本公开提供了一种生产式(5)化合物[C1]，即(4,5-二氢异噁唑-3-基)硫代甲脒盐化合物的工业上优选的、经济的和环保的方法。 本公开涉及一种方法，其中：通过在腈溶剂存在下使式（3）化合物与卤化剂反应，引起由反应式[C2]表示的反应，从而生成式（4）化合物，随后使式（4）化合物与异硫脲形成剂反应，从而生成式（5）化合物。
• PRODUCTION METHOD FOR 5,5-DI-SUBSTITUTED-4,5-DIHYDROISOXAZOLE
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：EP3789382A1

  公开（公告）日：2021-03-10

  The objective of the present invention is to provide a production method for a 4,5-dihydroisoxazole represented by formula (3), which is safe, industrially desirable, economical, and environmentally friendly. The present invention causes the compound of formula (1) to react with hydroxylamine in the presence of an acid catalyst to produce the compound of formula (3) through the reaction represented by the reaction equation.

  本发明的目的是提供一种以式（3）为代表的 4,5-二氢异噁唑的生产方法，该方法安全、工业上理想、经济且环保。 本发明使式（1）化合物在酸催化剂存在下与羟胺反应，通过反应方程式表示的反应生成式（3）化合物。