6-Imino-5-oxocyclohexa-1,3-dienecarboxylic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-Imino-5-oxocyclohexa-1,3-dienecarboxylic acid
• 英文别名: 6-imino-5-oxocyclohexa-1,3-diene-1-carboxylic acid
• 化学式: C₇H₅NO₃
• 分子量: 151.122
• InChiKey: BQEPLNUEGNSUTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Imino-5-oxocyclohexa-1,3-dienecarboxylic acid 、 3-羟基-2-氨基苯甲酸 在 氧气 、 酪氨酸酶 作用下， 生成 朱砂精酸
  参考文献：
  名称：

  Catalytic oxidation of o-aminophenols and aromatic amines by mushroom tyrosinase

  摘要：

  The kinetics of tyrosinase acting on o-aminophenols and aromatic amines as substrates was studied. The catalytic constants of aromatic monoamines and o-diamines were both low, these results are consistent with our previous mechanism in which the slow step is the transfer of a proton by a hydroxyl to the peroxide in oxy-tyrosinase (Fenoll et al., Biochem. J. 380 (2004) 643-650). In the case of o-aminophenols, the hydroxyl group indirectly cooperates in the transfer of the proton and consequently the catalytic constants in the action of tyrosinase on these compounds are higher. In the case of aromatic monoamines, the Michaelis constants are of the same order of magnitude than for monophenols, which suggests that the monophenols bind better (higher binding constant) to the enzyme to facilitate the pi-pi interactions between the aromatic ring and a possible histidine of the active site. In the case of aromatic o-diamines, both the catalytic and Michaelis constants are low, the values of the catalytic constants being lower than those of the corresponding o-diphenols. The values of the Michaelis constants of the aromatic o-diamines are slightly lower than those of their corresponding o-diphenols, confirming that the aromatic o-diamines bind less well (lower binding constant) to the enzyme. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.bbapap.2011.07.015
• 作为产物：
  描述：

  3-羟基-2-氨基苯甲酸 在 磷酸 、 氧气 、 维生素 C 、 酪氨酸酶 作用下， 生成 6-Imino-5-oxocyclohexa-1,3-dienecarboxylic acid
  参考文献：
  名称：

  酪氨酸酶自杀底物邻氨基酚和芳香族邻二胺的动力学表征。

  摘要：

  我们研究了作用于邻氨基酚和芳香族邻二胺的酪氨酸酶的自杀灭活，并将结果与​​相应邻邻二酚的结果进行了比较。催化常数遵循芳族邻二胺的顺序邻氨基酚>芳族邻二胺。

  DOI：

  10.1016/j.bbapap.2012.02.001

文献信息

• Ascorbate resistant detection of hydrogen peroxide
  申请人：Bayer Corporation

  公开号：EP0744619A1

  公开（公告）日：1996-11-27

  The present invention is a method for the detection of hydrogen peroxide in biological fluids or an aqueous solution which involves contacting the solution with an oxidation-reduction indicator and a transition metal complex. The transition metal complex is either a creatinine coordinated with iron or a guanidine coordinated with iron.

  本发明是一种检测生物液体或水溶液中过氧化氢的方法，包括将溶液与氧化还原指示剂和过渡金属络合物接触。过渡金属复合物是与铁配位的肌酸酐或与铁配位的胍。
• Yano, Yumihiko; Ikuta, Masato; Amamiya, Yoshiyuki, Chemistry Letters, 1991, # 3, p. 461 - 464
  作者：Yano, Yumihiko、Ikuta, Masato、Amamiya, Yoshiyuki、Nabeshima, Tatsuya

  DOI：——

  日期：——