But-2-enedioic acid;2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: But-2-enedioic acid;2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
• 化学式: C26H30F3N3O5S
• 分子量: 553.6
• InChiKey: NKGQWGWZXIYMHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE COMME ANTAGONISTES DU RÉCEPTEUR MCH
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2013105676A1

  公开（公告）日：2013-07-18

  The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol as defined in the specification, or a salt thereof.

  本发明提供了一种具有黑色素浓集激素受体拮抗作用并且用作预防或治疗肥胖等疾病的芳香环化合物。本发明涉及一种由式(I)表示的化合物，其中每个符号如规范中定义的，或其盐。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT DE TROUBLES MÉTABOLIQUES ET LEUR SYNTHÈSE
  申请人：UNIV NORTH CAROLINA

  公开号：WO2014165816A1

  公开（公告）日：2014-10-09

  The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

  本发明提供了式(I)化合物：其中变量X、Y、Z和R1如本文所述。本文所述的一些化合物是谷氨酸脱氢酶激活剂。本发明还涉及包含这些化合物的药物组合物、这些化合物和组合物在治疗代谢紊乱中的用途以及这些化合物的合成。
• Quinoline derivative
  申请人：Murata Toshiki

  公开号：US20120035213A1

  公开（公告）日：2012-02-09

  The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有黑色素浓集激素受体拮抗作用和低毒性的化合物，该化合物可用作肥胖等疾病的预防或治疗剂。本发明涉及一种由式（I）表示的化合物，其中每个符号如规范中定义的，或其盐。
• METHOD FOR TREATING/PREVENTING DISEASE USING COGNITIVE ABILITY OF CEREBRUM AND PHARMACEUTICAL
  申请人：Minowada Takuro

  公开号：US20110092548A1

  公开（公告）日：2011-04-21

  An object of the present invention is to develop a method of enhancing the cognitive ability of a brain to fundamentally cure a disease. It has been found out that, by using a medicament for treating or preventing a disease including a combination of a major tranquilizer, and vitamin C or a salt thereof and, if necessary, drip infusion, an antidepressant and an iron agent, the cognitive ability of a brain is enhanced, thus, an arbitrary disease including various cancers can be treated. The present invention also provides a method for treating or preventing a disease including a step of administering a major tranquilizer, and vitamin C or a salt thereof to a subject suffering from the disease.

  本发明的目的是开发一种增强大脑认知能力的方法，从根本上治愈疾病。研究发现，通过使用治疗或预防疾病的药物，包括主要的镇静剂、维生素C或其盐以及必要时的滴注输液、抗抑郁剂和铁剂的组合，可以增强大脑的认知能力，从而治疗包括各种癌症在内的任何疾病。本发明还提供了一种治疗或预防疾病的方法，包括给患有该疾病的受试者注射主要的镇静剂、维生素C或其盐的步骤。
• METHOD FOR PRODUCING PATCH, AND PATCH
  申请人：Hashimoto Eiji

  公开号：US20140037710A1

  公开（公告）日：2014-02-06

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug:the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产贴片的方法，包括形成支撑层和粘合层，其中粘合层的制备步骤是使用粘合层组合物通过混合一种碱金属二乙酸盐、一种药物和一种非水粘合基材料形成，使得药物和碱金属二乙酸盐的摩尔比（药物的摩尔数：碱金属二乙酸盐的摩尔数）在1:0.5到1:15之间。