2-[[(2R)-2,3-bis[[(9Z,12Z)-octadeca-9,12-dienoyl]oxy]propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[[(2R)-2,3-bis[[(9Z,12Z)-octadeca-9,12-dienoyl]oxy]propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C44H81NO8P+
• 分子量: 783.1
• InChiKey: FVXDQWZBHIXIEJ-LNDKUQBDSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  54
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• USE OF STORAGE STABLE VISCOUS PHOSPHOLIPID DEPOT TO TREAT WOUNDS
  申请人：Dr. Reddy's Laboratories SA.

  公开号：EP2629779B1

  公开（公告）日：2017-06-21
• Particulate-stabilized injectable pharmacutical compositions of posaconazole
  申请人：Witchey-Lakshmanan Leonore

  公开号：US20090226527A1

  公开（公告）日：2009-09-10

  The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient Posaconazole in an injectable suspension of particles that is stable when subjected to terminal sterilization. Preferred median particle sizes of between 1.5 and 3.0 microns are found to result in superior pharmacokinetic characteristics-displayed in FIG. 7.
• GAS-FILLED STABILIZED PARTICLES AND METHODS OF USE
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20160030596A1

  公开（公告）日：2016-02-04

  Provided herein are various gas-filled particles having a stabilized membrane that encapsulates the gas. Pharmaceutical compositions, methods of use and treatment, and methods of preparation are also described.
• SUSTAINED TIMOLOL MALEATE DELIVERY FROM LIPOSOMES FOR GLAUCOMA THERAPY AND OCCULAR HYPERTENSION
  申请人：Nanyang Technological University

  公开号：US20170246175A1

  公开（公告）日：2017-08-31

  Various embodiments relate to the field of liposomal formulations for drug delivery, in particular, liposomal formulations for ocular drug delivery. More specifically, various embodiments relate to sustained timolol maleate delivery from liposomes for glaucoma therapy and ocular hypertension.
• [EN] PHOSPHOLIPID COMPOSITIONS<br/>[FR] COMPOSITIONS DE PHOSOPHOLIPIDES
  申请人：MACHAVERT PHARMACEUTICALS LLC

  公开号：WO2018005735A9

  公开（公告）日：2018-02-01

  [EN] Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described.
  [FR] L'invention concerne des compositions comprenant un extrait de jaune d'oeuf modifié destiné à être utilisé en tant qu'agent anticancéreux efficace. L'extrait de jaune d'oeuf modifié comprend des fractions spécifiques de phosphatidylcholines et de sphingomyélines modifiées et produites à partir d'une synthèse chimique appliquée à l'extrait qui produisent un effet bénéfique sur l'inhibition de la croissance des cellules cancéreuses. L'invention concerne également des méthodes d'administration de ces compositions.