Prochlorperazine sulfoxide, 4'-oxide | 879495-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: Prochlorperazine sulfoxide, 4'-oxide
• 英文别名: 2-chloro-10-[3-(4-methyl-4-oxidopiperazin-4-ium-1-yl)propyl]phenothiazine 5-oxide
• CAS: 879495-68-8
• 化学式: C20H24ClN3O2S
• 分子量: 405.9
• InChiKey: QOBHEEKSQZNSKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHOD FOR TREATING DRUG RESISTANT CANCER
  申请人：NATIONAL YANG MING UNIVERSITY

  公开号：US20170105999A1

  公开（公告）日：2017-04-20

  The present invention relates to a method for treating a subject with a cancer resistant to a chemotherapeutic drug comprising administering to said subject a therapeutically effective amount of prochlorperazine or its analog or metabolite, or a pharmaceutically acceptable salt thereof, in combination of the chemotherapeutic drug. The present invention also relates to a method for preventing cancer metastasis with the combination of prochlorperazine in combination of a chemotherapeutic drug.