N,N-diisopropyl-3-(2-naphthyl)propan-1-amine | 1147862-94-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-diisopropyl-3-(2-naphthyl)propan-1-amine
• 英文别名: 3-naphthalen-2-yl-N,N-di(propan-2-yl)propan-1-amine
• CAS: 1147862-94-9
• 化学式: C₁₉H₂₇N
• 分子量: 269.43
• InChiKey: PBMKMBDQQDTBTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二异丙胺 、 3-萘-2-基-丙醛 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 反应 17.0h， 以55.1 mg的产率得到N,N-diisopropyl-3-(2-naphthyl)propan-1-amine
  参考文献：
  名称：

  Lewis Base-Promoted Hydrosilylation of Cyclic Malonates: Synthesis of β-Substituted Aldehydes and γ-Substituted Amines

  摘要：

  The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of beta-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The utility of the method is demonstrated in a number of examples and further in the synthesis of gamma-substituted propylamines in a one-pot hydrosilylation/reductive amination process.

  DOI：

  10.1021/jo900390d

文献信息

• Lewis Base-Promoted Hydrosilylation of Cyclic Malonates: Synthesis of β-Substituted Aldehydes and γ-Substituted Amines
  作者：Christopher G. Frost、Benjamin C. Hartley

  DOI：10.1021/jo900390d

  日期：2009.5.1

  The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of beta-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The utility of the method is demonstrated in a number of examples and further in the synthesis of gamma-substituted propylamines in a one-pot hydrosilylation/reductive amination process.