3-Chloro-7-trifluoromethyl-quinoxaline-2-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-Chloro-7-trifluoromethyl-quinoxaline-2-carbonitrile
• 英文别名: 3-Chloro-7-(trifluoromethyl)quinoxaline-2-carbonitrile
• 化学式: C₁₀H₃ClF₃N₃
• 分子量: 257.602
• InChiKey: YJGMUKQDCRIHJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙二腈 、 5-trifluoromethylbenzofuroxan 生成 3-Chloro-7-trifluoromethyl-quinoxaline-2-carbonitrile 、 3-Chloro-6-trifluoromethyl-2-quinoxalinecarbonitrile
  参考文献：
  名称：

  Synthesis and antituberculosis activity of some new 2-quinoxalinecarbonitriles

  摘要：

  Tuberculosis, an ancient disease undergoing recent control by public hygiene and drug therapy, has experienced a recrudescence throughout the world. New and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitriles have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00067-6

文献信息

• Synthesis and antituberculosis activity of some new 2-quinoxalinecarbonitriles
  作者：M.Elena Montoya、Yolanda Sainz、M.Angel Ortega、Adela Lopez De Cerain、Antonio Monge

  DOI：10.1016/s0014-827x(98)00067-6

  日期：1998.8

  Tuberculosis, an ancient disease undergoing recent control by public hygiene and drug therapy, has experienced a recrudescence throughout the world. New and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitriles have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening. (C) 1998 Elsevier Science S.A. All rights reserved.