4-Amino-1-[(2r,5s)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; 1-[(2r,5s)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 4-Amino-1-[(2r,5s)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; 1-[(2r,5s)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• 英文别名: 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C19H25N5O7
• 分子量: 435.4
• InChiKey: BBCRCTDRTDYLJT-CIHJXTAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.21
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  167
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] BROMODOMAIN INHIBITORS<br/>[FR] INHIBITEURS DE BROMODOMAINE
  申请人：ABBVIE INC

  公开号：WO2014206150A1

  公开（公告）日：2014-12-31

  The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

  本发明提供了式（I）的化合物。其中Rx、Ry、Rx1、L1、G1、A1、A2、A3和A4具有规范中定义的任何值，并且其药学上可接受的盐，可用作治疗疾病和病症的药剂，包括炎症性疾病、癌症和艾滋病。还提供了由一种或多种式（I）的化合物组成的药物组合物。
• [EN] PYRIDINONE AND PYRIDAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRIDINONE ET DE PYRIDAZINONE
  申请人：ABBOTT LAB

  公开号：WO2013185284A1

  公开（公告）日：2013-12-19

  Compounds of formula (I) wherein A1, A2, A3, A4, J, L, G, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS are disclosed. Pharmaceutical compositions comprising one or more compounds of formula (I) also are disclosed.

  公式（I）中A1、A2、A3、A4、J、L、G和R1的化合物，其取值符合规范中定义的任何值，以及其药学上可接受的盐，可用作治疗疾病和病况的药物，包括炎症性疾病、糖尿病、肥胖症、癌症和艾滋病。还披露了包含一个或多个公式（I）化合物的药物组合物。
• [EN] ISOINDOLONE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISO-INDOLONE
  申请人：ABBOTT LAB

  公开号：WO2013155695A1

  公开（公告）日：2013-10-24

  Provided are compounds of formula (I), wherein A, Y, J, R1, R2, and R3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

  提供了化合物的公式（I），其中A、Y、J、R1、R2和R3具有规范中定义的任何值，以及其药学上可接受的盐，这些化合物可用作治疗疾病和症状的药物，包括炎症性疾病、糖尿病、肥胖症、癌症和艾滋病的药物。还提供了包含一个或多个公式（I）化合物的药物组合物。
• ISOINDOLONE DERIVATIVES
  申请人：AbbVie Inc.

  公开号：US20130281450A1

  公开（公告）日：2013-10-24

  The present invention provides for compounds of formula (I) wherein A, Y, J, R 1 , R 2 , and R 3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula I.

  本发明提供了一种化合物，其化学式为(I)，其中A、Y、J、R1、R2和R3可以取规范中定义的任何值，以及其药用盐，这些化合物在治疗疾病和病症方面非常有用，包括炎症性疾病、糖尿病、肥胖、癌症和艾滋病。还提供了包含一种或多种化合物的药物组合物，其化学式为I。
• BROMODOMAIN INHIBITORS
  申请人：AbbVie Inc.

  公开号：US20150158873A1

  公开（公告）日：2015-06-11

  The present invention provides for compounds of formula (I) wherein Y 1 , Y 2 , R 1 , R 2 , R 3 , A 1 , A 2 , A 3 , and A 4 , have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

  本发明提供了以下式（I）的化合物，其中Y1、Y2、R1、R2、R3、A1、A2、A3和A4的取值如规范中定义，以及其药学上可接受的盐，这些化合物可用作治疗疾病和病症的药物，包括炎症性疾病、癌症和艾滋病。还提供了由一个或多个式（I）化合物组成的药物组合物。