DB673

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: DB673
• 英文别名: 2,5-bis-(4-guanidinophenyl)furan；1-[4-[5-(4-Guanidinophenyl)-2-furyl]phenyl]guanidine；2-[4-[5-[4-(diaminomethylideneamino)phenyl]furan-2-yl]phenyl]guanidine
• 化学式: C₁₈H₁₈N₆O
• 分子量: 334.381
• InChiKey: IFKOKKYJMCJYSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-bis(4-aminophenyl)furan 在 盐酸 、 TEA 、 mercury dichloride 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 DB673
  参考文献：
  名称：

  The activity of diguanidino and ‘reversed’ diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

  摘要：

  The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC50 values of less than 1 mumol versus T. cruzi and five gave similar values versus L. donovani. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00319-6

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES ET LA POTENTIALISATION D'ANTIBIOTIQUES
  申请人：UNIV GEORGIA STATE RES FOUND

  公开号：WO2021127452A1

  公开（公告）日：2021-06-24

  Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.

  本文提供了用于治疗由革兰氏阳性细菌、革兰氏阴性细菌和/或分枝杆菌引起的细菌感染的化合物和方法。本文还提供了用于增强抗生素在治疗细菌感染中的效果的化合物和方法。还提供了包括本文所述化合物的药物组合物。
• Dicationic Compounds For Activity Against Trichomonas Vaginalis
  申请人：Boykin W. David

  公开号：US20070276020A1

  公开（公告）日：2007-11-29

  Dicationic compounds for the treatment of T. vaginalis infections are described. The presently described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Furthermore, the presently described compounds demonstrate IC 50 concentrations that were not elevated in the metronidazole resistant isolate, suggesting that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles.

  本文描述了用于治疗T. vaginalis感染的二价化合物。目前描述的化合物在体外对甲硝唑敏感和耐药的T. vaginalis分离株具有活性。此外，目前描述的化合物表现出的IC50浓度在甲硝唑耐药分离株中没有升高，表明它们的活性不受寄生虫机制的影响，这些机制使其对5-硝基咪唑类药物产生耐药性。
• Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
  申请人：——

  公开号：US20020156098A1

  公开（公告）日：2002-10-24

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula 1 wherein Y is a heteroatom; R 1 and R 2 are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X 1 , X 2 , and X 3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, acylamino, alkylthio, sulfonyl, cyano, carboxy, alkoxycarbonyl, or carbamoyl group are disclosed.

  本发明涉及用于治疗、预防或抑制利什曼病的方法，包括向受试者施用至少一种具有结构式1的化合物的治疗有效量，其中Y是杂原子；R1和R2分别是H或烷基、环烷基、杂环烷基、芳基、氨基或杂芳基基团；X1、X2和X3分别是H或烷基、烷氧基、卤素、氨基、烷基氨基、二烷基氨基、酰胺基、烷硫基、磺酰基、氰基、羧基、烷氧羰基或氨基甲酰基基团。
• Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
  申请人：Dykstra C. Christine

  公开号：US20070072877A1

  公开（公告）日：2007-03-29

  The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

  本发明涉及一种新型化合物和方法，可用于治疗黄病毒科家族的病毒成员。本发明的化合物将具有根据本申请中所述的公式（I）-（VI）的结构。
• COMPOUNDS, METHODS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF BOVINE VIRAL DIARRHEA VIRUS (BVDV) INFECTION AND HEPATITIS C VIRUS (HCV) INFECTION
  申请人：Dykstra C. Christine

  公开号：US20070010533A1

  公开（公告）日：2007-01-11

  The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

  本发明涉及新型化合物和方法，可用于治疗Flaviviridae病毒家族成员。本发明的化合物将具有根据本申请中所述的公式（I）-（VI）的结构。