9-(2'-azido-2'-deoxy-β-D-erythro-oxetanosyl)-adenine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2'-azido-2'-deoxy-β-D-erythro-oxetanosyl)-adenine
• 英文别名: [4-(6-Amino-purin-9-yl)-3-azido-oxetan-2-yl]-methanol；[(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-azidooxetan-2-yl]methanol
• 化学式: C₉H₁₀N₈O₂
• 分子量: 262.231
• InChiKey: NXTMDIWLVQSUHF-UDJQAZALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  9-((2R,3R,4S)-3-Azido-4-trityloxymethyl-oxetan-2-yl)-9H-purin-6-ylamine 在 三氟乙酸 作用下， 以 甲醇 为溶剂， 以95%的产率得到9-(2'-azido-2'-deoxy-β-D-erythro-oxetanosyl)-adenine
  参考文献：
  名称：

  Oxetane nucleosides with fluorine and azide substitutents: nucleophilic displacements on an oxetane ring

  摘要：

  Flourine and azide substituents are introduced into an oxetane ring by nucleophilic displacement reactions; the syntheses and anti-viral activities of 9-(2'-azido-2'-deoxy-beta-D-erythro-oxetanosyl)-adenine and of 9-(2'-deoxy-2'-fluoro-beta-D-erythro-oxetanosyl)-adenine are reported.

  DOI：

  10.1016/s0040-4039(00)74302-4

文献信息

• Oxetane nucleosides with fluorine and azide substitutents: nucleophilic displacements on an oxetane ring
  作者：Y. Wang、G.W.J. Fleet、F.X. Wilson、R. Storer、C.J. Wallis、O. Doherty、D.J. Watkin、K. Vogt、D.R. Witty、J.M. Peach

  DOI：10.1016/s0040-4039(00)74302-4

  日期：1991.3

  Flourine and azide substituents are introduced into an oxetane ring by nucleophilic displacement reactions; the syntheses and anti-viral activities of 9-(2'-azido-2'-deoxy-beta-D-erythro-oxetanosyl)-adenine and of 9-(2'-deoxy-2'-fluoro-beta-D-erythro-oxetanosyl)-adenine are reported.