Aciclovir & Ganciclovir

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Aciclovir & Ganciclovir
• 英文别名: 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one;2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one
• 化学式: C17H24N10O7
• 分子量: 480.4
• InChiKey: STWAXJXLULADGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  250
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Prevention and Treatment of Cancer and Other Diseases
  申请人：Bondarev Igor E.

  公开号：US20090203636A1

  公开（公告）日：2009-08-13

  Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.

  本文披露了与脱氧核糖核酸（DNA）或核糖核酸（RNA）的特定结构相互作用的核苷类化合物。这些化合物干扰端粒酶和反转录酶的活性，并且可用作抗病毒、抗菌和抗癌剂。本文还披露了一种治疗或预防患者癌症的方法，包括向患者细胞中表达的反转录酶（RTs）的抑制剂或拮抗剂的组合物的治疗有效量的给药。本文还披露了使用核苷类类似物和其他RTs抑制剂与DNA损伤剂（如基因毒性剂、辐射或光动力疗法）或这些剂的组合物相结合治疗各种癌症的方法。
• Gene-trap identification of host cell proteins required for hepatitis C virus replication
  申请人：——

  公开号：US20030004329A1

  公开（公告）日：2003-01-02

  Provided are methods that facilitate the identification of host cell genes required for the replication of hepatitis C virus. Also provided are methods of identifying compounds that inhibit the activity(ies) of products of these genes required for hepatitis C virus replication in host cells, and that therefore inhibit hepatitis C virus replication in such cells. These compounds are useful as hepatitis C virus antiviral pharmaceutical agents to treat or prevent hepatitis C virus infections in humans. Also provided are novel host cell genes identified by these methods; hepatitis C virus replicons comprising both a positive and a negative selectable marker gene; and cell lines comprising said replicons.

  本发明提供了有助于鉴定丙型肝炎病毒复制所需的宿主细胞基因的方法。还提供了鉴定化合物的方法，这些化合物可抑制宿主细胞中丙型肝炎病毒复制所需的这些基因的产物的活性，从而抑制丙型肝炎病毒在这些细胞中的复制。这些化合物可作为丙型肝炎病毒抗病毒药物，用于治疗或预防人类感染丙型肝炎病毒。此外，还提供了通过这些方法鉴定出的新型宿主细胞基因；包含阳性和阴性可选择标记基因的丙型肝炎病毒复制子；以及包含上述复制子的细胞系。
• THYMIDINE KINASE MUTANTS AND FUSION PROTEINS HAVING THYMIDINE KINASE AND GUANYLATE KINASE ACTIVITIES
  申请人：DARWIN MOLECULAR CORPORATION

  公开号：EP1025212A2

  公开（公告）日：2000-08-09
• CELLULAR AND ANIMAL MODELS FOR DISEASES ASSOCIATED WITH ALTERED MITOCHONDRIAL FUNCTION
  申请人：Mitokor

  公开号：EP1076691A1

  公开（公告）日：2001-02-21
• PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES
  申请人：Alt Solutions, Inc.

  公开号：EP2001488A2

  公开（公告）日：2008-12-17