2-amino-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1H-purin-6-one; phosphonoformic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1H-purin-6-one; phosphonoformic acid
• 英文别名: 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one;phosphonoformic acid
• 化学式: C10H16N5O9P
• 分子量: 381.24
• InChiKey: LUAUCDBVPWRRSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.13
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  230
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Nucleic acids, proteins, and antibodies
  申请人：Human Genome Sciences, Inc.

  公开号：US20040005575A1

  公开（公告）日：2004-01-08

  The present invention relates to novel cardiovascular system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as “cardiovascular system antigens,” and the use of such cardiovascular system antigens for detecting disorders of the cardiovascular system, particularly the presence of cancer of cardiovascular system tissues and cancer metastases. More specifically, isolated cardiovascular system associated nucleic acid molecules are provided encoding novel cardiovascular system associated polypeptides. Novel cardiovascular system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human cardiovascular system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the cardiovascular system, including cancer of cardiovascular system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

  本发明涉及新型心血管系统相关多核苷酸和由这些多核苷酸编码的多肽，在此统称为 "心血管系统抗原"，以及使用这种心血管系统抗原检测心血管系统疾病，特别是心血管系统组织是否存在癌症和癌症转移。更具体地说，提供了编码新型心血管系统相关多肽的分离心血管系统相关核酸分子。还提供了新型心血管系统多肽和与这些多肽结合的抗体。本发明还提供了生产人类心血管系统相关多核苷酸和/或多肽的载体、宿主细胞以及重组和合成方法。本发明进一步涉及用于诊断、治疗、预防和/或预后心血管系统相关疾病（包括心血管系统组织癌症）的诊断和治疗方法，以及治疗此类疾病的治疗方法。本发明进一步涉及鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及抑制本发明多肽的产生和功能的方法和/或组合物。
• LIPID PRODRUGS FOR ORAL ADMINISTRATION
  申请人：VESTAR, INC.

  公开号：EP0674529A1

  公开（公告）日：1995-10-04
• CHEMOKINE BETA-7
  申请人：Human Genome Sciences, Inc.

  公开号：EP1129193A1

  公开（公告）日：2001-09-05
• EP1129193A4
  申请人：——

  公开号：EP1129193A4

  公开（公告）日：2005-08-10
• 45 HUMAN SECRETED PROTEINS
  申请人：HUMAN GENOME SCIENCES, INC.

  公开号：EP1165827A1

  公开（公告）日：2002-01-02